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Transcription regulation and animal diversity

Author

Listed:
  • Michael Levine

    (Center for Integrative Genomics)

  • Robert Tjian

    (Center for Integrative Genomics
    University of California, Berkeley)

Abstract

Whole-genome sequence assemblies are now available for seven different animals, including nematode worms, mice and humans. Comparative genome analyses reveal a surprising constancy in genetic content: vertebrate genomes have only about twice the number of genes that invertebrate genomes have, and the increase is primarily due to the duplication of existing genes rather than the invention of new ones. How, then, has evolutionary diversity arisen? Emerging evidence suggests that organismal complexity arises from progressively more elaborate regulation of gene expression.

Suggested Citation

  • Michael Levine & Robert Tjian, 2003. "Transcription regulation and animal diversity," Nature, Nature, vol. 424(6945), pages 147-151, July.
    • Handle: RePEc:nat:nature:v:424:y:2003:i:6945:d:10.1038_nature01763
    DOI: 10.1038/nature01763
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    Cited by:

    1. James M Billingsley & Premeela A Rajakumar & Michelle A Connole & Nadine C Salisch & Sama Adnan & Yury V Kuzmichev & Henoch S Hong & R Keith Reeves & Hyung-joo Kang & Wenjun Li & Qingsheng Li & Ashley, 2015. "Characterization of CD8+ T Cell Differentiation following SIVΔnef Vaccination by Transcription Factor Expression Profiling," PLOS Pathogens, Public Library of Science, vol. 11(3), pages 1-23, March.
    2. Erik Andrews & Yue Wang & Tian Xia & Wenqing Cheng & Chao Cheng, 2017. "Contextual Refinement of Regulatory Targets Reveals Effects on Breast Cancer Prognosis of the Regulome," PLOS Computational Biology, Public Library of Science, vol. 13(1), pages 1-20, January.
    3. Alex N Nguyen Ba & Bob Strome & Jun Jie Hua & Jonathan Desmond & Isabelle Gagnon-Arsenault & Eric L Weiss & Christian R Landry & Alan M Moses, 2014. "Detecting Functional Divergence after Gene Duplication through Evolutionary Changes in Posttranslational Regulatory Sequences," PLOS Computational Biology, Public Library of Science, vol. 10(12), pages 1-15, December.
    4. Kirsten H ten Tusscher & Paulien Hogeweg, 2011. "Evolution of Networks for Body Plan Patterning; Interplay of Modularity, Robustness and Evolvability," PLOS Computational Biology, Public Library of Science, vol. 7(10), pages 1-16, October.
    5. Armita Nourmohammad & Michael Lässig, 2011. "Formation of Regulatory Modules by Local Sequence Duplication," PLOS Computational Biology, Public Library of Science, vol. 7(10), pages 1-12, October.
    6. Aria Ronsmans & Maxime Wery & Ugo Szachnowski & Camille Gautier & Marc Descrimes & Evelyne Dubois & Antonin Morillon & Isabelle Georis, 2019. "Transcription-dependent spreading of the Dal80 yeast GATA factor across the body of highly expressed genes," PLOS Genetics, Public Library of Science, vol. 15(2), pages 1-31, February.
    7. Mitsutaka Kadota & Howard H Yang & Nan Hu & Chaoyu Wang & Ying Hu & Philip R Taylor & Kenneth H Buetow & Maxwell P Lee, 2007. "Allele-Specific Chromatin Immunoprecipitation Studies Show Genetic Influence on Chromatin State in Human Genome," PLOS Genetics, Public Library of Science, vol. 3(5), pages 1-11, May.
    8. Buki Kwon & Mervin M. Fansler & Neil D. Patel & Jihye Lee & Weirui Ma & Christine Mayr, 2022. "Enhancers regulate 3′ end processing activity to control expression of alternative 3′UTR isoforms," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    9. Xiaoyu Tu & Sibo Ren & Wei Shen & Jianjian Li & Yuxiang Li & Chuanshun Li & Yangmeihui Li & Zhanxiang Zong & Weibo Xie & Donald Grierson & Zhangjun Fei & Jim Giovannoni & Pinghua Li & Silin Zhong, 2022. "Limited conservation in cross-species comparison of GLK transcription factor binding suggested wide-spread cistrome divergence," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    10. Timothy H-C Hsiau & Claudiu Diaconu & Connie A Myers & Jongwoo Lee & Constance L Cepko & Joseph C Corbo, 2007. "The Cis-regulatory Logic of the Mammalian Photoreceptor Transcriptional Network," PLOS ONE, Public Library of Science, vol. 2(7), pages 1-16, July.

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