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p53 mutant mice that display early ageing-associated phenotypes

Author

Listed:
  • Stuart D. Tyner

    (Cell and Molecular Biology Program)

  • Sundaresan Venkatachalam

    (Department of Molecular Virology and Microbiology)

  • Jene Choi

    (Department of Molecular Virology and Microbiology)

  • Stephen Jones

    (University of Massachusetts Medical Center)

  • Nader Ghebranious

    (Marshfield Medical Research Foundation)

  • Herbert Igelmann

    (Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie an der Universitat Hamburg)

  • Xiongbin Lu

    (Department of Molecular Virology and Microbiology)

  • Gabrielle Soron

    (Department of Molecular Virology and Microbiology)

  • Benjamin Cooper

    (Department of Molecular Virology and Microbiology)

  • Cory Brayton

    (Center for Comparative Medicine)

  • Sang Hee Park

    (Scott Department of Urology)

  • Timothy Thompson

    (Scott Department of Urology)

  • Gerard Karsenty

    (Department of Human and Molecular Genetics
    The Sanger Centre, Wellcome Trust Genome Campus)

  • Allan Bradley

    (Department of Human and Molecular Genetics
    The Sanger Centre, Wellcome Trust Genome Campus)

  • Lawrence A. Donehower

    (Department of Molecular Virology and Microbiology
    Baylor College of Medicine)

Abstract

The p53 tumour suppressor is activated by numerous stressors to induce apoptosis, cell cycle arrest, or senescence. To study the biological effects of altered p53 function, we generated mice with a deletion mutation in the first six exons of the p53 gene that express a truncated RNA capable of encoding a carboxy-terminal p53 fragment. This mutation confers phenotypes consistent with activated p53 rather than inactivated p53. Mutant (p53+/m) mice exhibit enhanced resistance to spontaneous tumours compared with wild-type (p53+/+) littermates. As p53+/m mice age, they display an early onset of phenotypes associated with ageing. These include reduced longevity, osteoporosis, generalized organ atrophy and a diminished stress tolerance. A second line of transgenic mice containing a temperature-sensitive mutant allele of p53 also exhibits early ageing phenotypes. These data suggest that p53 has a role in regulating organismal ageing.

Suggested Citation

  • Stuart D. Tyner & Sundaresan Venkatachalam & Jene Choi & Stephen Jones & Nader Ghebranious & Herbert Igelmann & Xiongbin Lu & Gabrielle Soron & Benjamin Cooper & Cory Brayton & Sang Hee Park & Timothy, 2002. "p53 mutant mice that display early ageing-associated phenotypes," Nature, Nature, vol. 415(6867), pages 45-53, January.
    • Handle: RePEc:nat:nature:v:415:y:2002:i:6867:d:10.1038_415045a
    DOI: 10.1038/415045a
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    Cited by:

    1. Ali Doğa Yücel & Vadim N. Gladyshev, 2024. "The long and winding road of reprogramming-induced rejuvenation," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    2. Jean-Philippe Coppé & Christopher K Patil & Francis Rodier & Yu Sun & Denise P Muñoz & Joshua Goldstein & Peter S Nelson & Pierre-Yves Desprez & Judith Campisi, 2008. "Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor," PLOS Biology, Public Library of Science, vol. 6(12), pages 1-1, December.

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