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Dendritic cells and the control of immunity

Author

Listed:
  • Jacques Banchereau

    (Baylor Institute for Immunology, Research, Baylor Research Institute
    Laboratory of Cellular Physiology and Immunology, Rockefeller University)

  • Ralph M. Steinman

    (Baylor Institute for Immunology, Research, Baylor Research Institute
    Laboratory of Cellular Physiology and Immunology, Rockefeller University)

Abstract

B and T lymphocytes are the mediators of immunity, but their function is under the control of dendritic cells. Dendritic cells in the periphery capture and process antigens, express lymphocyte co-stimulatory molecules, migrate to lymphoid organs and secrete cytokines to initiate immune responses. They not only activate lymphocytes, they also tolerize T cells to antigens that are innate to the body (self-antigens), thereby minimizing autoimmune reactions. Once a neglected cell type, dendritic cells can now be readily obtained in sufficient quantities to allow molecular and cell biological analysis. With knowledge comes the realization that these cells are a powerful tool for manipulating the immune system.

Suggested Citation

  • Jacques Banchereau & Ralph M. Steinman, 1998. "Dendritic cells and the control of immunity," Nature, Nature, vol. 392(6673), pages 245-252, March.
    • Handle: RePEc:nat:nature:v:392:y:1998:i:6673:d:10.1038_32588
    DOI: 10.1038/32588
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    4. Yael Korem & Pablo Szekely & Yuval Hart & Hila Sheftel & Jean Hausser & Avi Mayo & Michael E Rothenberg & Tomer Kalisky & Uri Alon, 2015. "Geometry of the Gene Expression Space of Individual Cells," PLOS Computational Biology, Public Library of Science, vol. 11(7), pages 1-27, July.
    5. Kulvinder Kochar Kaur & Gautam Allahbadia & Mandeep Singh, 2016. "Advances in the Therapy of Advanced Ovarian Cancer-Special Emphasis on the PD1/PDL1 Pathway," Current Trends in Biomedical Engineering & Biosciences, Juniper Publishers Inc., vol. 1(2), pages 32-40, December.
    6. Bangyuan Wu & Hengmin Cui & Xi Peng & Jing Fang & Zhicai Zuo & Junliang Deng & Jianying Huang, 2014. "Analysis of the Toll-Like Receptor 2-2 (TLR2-2) and TLR4 mRNA Expression in the Intestinal Mucosal Immunity of Broilers Fed on Diets Supplemented with Nickel Chloride," IJERPH, MDPI, vol. 11(1), pages 1-14, January.
    7. Chang Su & Dongsoo Lee & Peng Jin & Jingfei Zhang, 2025. "scMultiMap: Cell-type-specific mapping of enhancers and target genes from single-cell multimodal data," Nature Communications, Nature, vol. 16(1), pages 1-12, December.
    8. Iraj Hosseini & Lucio Gama & Feilim Mac Gabhann, 2015. "Multiplexed Component Analysis to Identify Genes Contributing to the Immune Response during Acute SIV Infection," PLOS ONE, Public Library of Science, vol. 10(5), pages 1-28, May.
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    12. K. Brad Wray & Søren R. Paludan & Lutz Bornmann & Robin Haunschild, 2024. "Using Reference Publication Year Spectroscopy (RPYS) to analyze the research and publication culture in immunology," Scientometrics, Springer;Akadémiai Kiadó, vol. 129(6), pages 3271-3283, June.
    13. Fangting Zhou & Kejun He & James J. Cai & Laurie A. Davidson & Robert S. Chapkin & Yang Ni, 2023. "A Unified Bayesian Framework for Bi-overlapping-Clustering Multi-omics Data via Sparse Matrix Factorization," Statistics in Biosciences, Springer;International Chinese Statistical Association, vol. 15(3), pages 669-691, December.
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    17. Bay Vagher & Eyal Amiel, 2024. "Detection of nitric oxide-mediated metabolic effects using real-time extracellular flux analysis," PLOS ONE, Public Library of Science, vol. 19(3), pages 1-22, March.

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