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Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy

Author

Listed:
  • Qian Chen

    (Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University)

  • Ligeng Xu

    (Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University)

  • Chao Liang

    (Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University)

  • Chao Wang

    (Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University)

  • Rui Peng

    (Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University)

  • Zhuang Liu

    (Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University)

Abstract

A therapeutic strategy that can eliminate primary tumours, inhibit metastases, and prevent tumour relapses is developed herein by combining adjuvant nanoparticle-based photothermal therapy with checkpoint-blockade immunotherapy. Indocyanine green (ICG), a photothermal agent, and imiquimod (R837), a Toll-like-receptor-7 agonist, are co-encapsulated by poly(lactic-co-glycolic) acid (PLGA). The formed PLGA-ICG-R837 nanoparticles composed purely by three clinically approved components can be used for near-infrared laser-triggered photothermal ablation of primary tumours, generating tumour-associated antigens, which in the presence of R837-containing nanoparticles as the adjuvant can show vaccine-like functions. In combination with the checkpoint-blockade using anti-cytotoxic T-lymphocyte antigen-4 (CTLA4), the generated immunological responses will be able to attack remaining tumour cells in mice, useful in metastasis inhibition, and may potentially be applicable for various types of tumour models. Furthermore, such strategy offers a strong immunological memory effect, which can provide protection against tumour rechallenging post elimination of their initial tumours.

Suggested Citation

  • Qian Chen & Ligeng Xu & Chao Liang & Chao Wang & Rui Peng & Zhuang Liu, 2016. "Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy," Nature Communications, Nature, vol. 7(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms13193
    DOI: 10.1038/ncomms13193
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    Cited by:

    1. Rong Sun & Mingzhu Liu & Jianping Lu & Binbin Chu & Yunmin Yang & Bin Song & Houyu Wang & Yao He, 2022. "Bacteria loaded with glucose polymer and photosensitive ICG silicon-nanoparticles for glioblastoma photothermal immunotherapy," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Kaiyuan Wang & Yang Li & Xia Wang & Zhijun Zhang & Liping Cao & Xiaoyuan Fan & Bin Wan & Fengxiang Liu & Xuanbo Zhang & Zhonggui He & Yingtang Zhou & Dong Wang & Jin Sun & Xiaoyuan Chen, 2023. "Gas therapy potentiates aggregation-induced emission luminogen-based photoimmunotherapy of poorly immunogenic tumors through cGAS-STING pathway activation," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    3. Huapan Fang & Zhaopei Guo & Jie Chen & Lin Lin & Yingying Hu & Yanhui Li & Huayu Tian & Xuesi Chen, 2021. "Combination of epigenetic regulation with gene therapy-mediated immune checkpoint blockade induces anti-tumour effects and immune response in vivo," Nature Communications, Nature, vol. 12(1), pages 1-19, December.
    4. Yue Yan & Binlong Chen & Qingqing Yin & Zenghui Wang & Ye Yang & Fangjie Wan & Yaoqi Wang & Mingmei Tang & Heming Xia & Meifang Chen & Jianxiong Liu & Siling Wang & Qiang Zhang & Yiguang Wang, 2022. "Dissecting extracellular and intracellular distribution of nanoparticles and their contribution to therapeutic response by monochromatic ratiometric imaging," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    5. Kaiyuan Wang & Xuanbo Zhang & Hao Ye & Xia Wang & Zhijin Fan & Qi Lu & Songhao Li & Jian Zhao & Shunzhe Zheng & Zhonggui He & Qianqian Ni & Xiaoyuan Chen & Jin Sun, 2023. "Biomimetic nanovaccine-mediated multivalent IL-15 self-transpresentation (MIST) for potent and safe cancer immunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    6. Li, Zhijing & Lei, Hui & Kan, Ankang & Xie, Huaqing & Yu, Wei, 2021. "Photothermal applications based on graphene and its derivatives: A state-of-the-art review," Energy, Elsevier, vol. 216(C).
    7. Xin Li & Tuying Yong & Zhaohan Wei & Nana Bie & Xiaoqiong Zhang & Guiting Zhan & Jianye Li & Jiaqi Qin & Jingjing Yu & Bixiang Zhang & Lu Gan & Xiangliang Yang, 2022. "Reversing insufficient photothermal therapy-induced tumor relapse and metastasis by regulating cancer-associated fibroblasts," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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