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A node-localized efflux transporter for loading iron to developing tissues in rice

Author

Listed:
  • Jing Che

    (Chinese Academy of Sciences
    Okayama University
    University of Chinese Academy of Sciences)

  • Sheng Huang

    (Okayama University)

  • Yuting Qu

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Yuma Yoshioka

    (Okayama University
    Okayama University)

  • Chiyuri Tomita

    (Okayama University
    Okayama University)

  • Takaaki Miyaji

    (Okayama University
    Okayama University)

  • Zhenyang Liu

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Renfang Shen

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Naoki Yamaji

    (Okayama University)

  • Jian Feng Ma

    (Okayama University)

Abstract

Iron (Fe) is an essential micronutrient for plant growth and development. It plays crucial roles in various organs and tissues of plants, but the molecular mechanisms governing its distribution to the above-ground parts after root uptake remain unclear. In this study, we identify OsIET1 (Oryza sativa Iron Efflux Transporter 1), a rice gene highly expressed in the nodes. OsIET1 encodes a plasma membrane-localized protein, which shows efflux transport activity for ferrous iron. It is predominantly expressed in the xylem regions of diffuse vascular bundles, and its expression is upregulated under high Fe conditions. Disruption of OsIET1 impairs Fe allocation, reducing Fe transport to developing tissues (young leaves and grains), while increasing accumulation in nodes and older leaves. This misdistribution causes chlorosis in young leaves and decreases grain yield, especially under Fe-deficient conditions. Furthermore, we detect excessive Fe deposition around the xylem of diffuse vascular bundles in the nodes. Given the pivotal role of nodes in mineral distribution, our results indicate that OsIET1 mediates inter-vascular Fe transfer by facilitating Fe loading into the xylem of diffuse vascular bundles. This process ensures preferential Fe delivery to developing tissues, thereby promoting optimal plant growth and productivity.

Suggested Citation

  • Jing Che & Sheng Huang & Yuting Qu & Yuma Yoshioka & Chiyuri Tomita & Takaaki Miyaji & Zhenyang Liu & Renfang Shen & Naoki Yamaji & Jian Feng Ma, 2025. "A node-localized efflux transporter for loading iron to developing tissues in rice," Nature Communications, Nature, vol. 16(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-64863-4
    DOI: 10.1038/s41467-025-64863-4
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    References listed on IDEAS

    as
    1. Naoki Yamaji & Akimasa Sasaki & Ji Xing Xia & Kengo Yokosho & Jian Feng Ma, 2013. "A node-based switch for preferential distribution of manganese in rice," Nature Communications, Nature, vol. 4(1), pages 1-11, December.
    2. Naoki Yamaji & Yuma Takemoto & Takaaki Miyaji & Namiki Mitani-Ueno & Kaoru T. Yoshida & Jian Feng Ma, 2017. "Erratum: Reducing phosphorus accumulation in rice grains with an impaired transporter in the node," Nature, Nature, vol. 543(7643), pages 136-136, March.
    3. Naoki Yamaji & Yuma Takemoto & Takaaki Miyaji & Namiki Mitani-Ueno & Kaoru T. Yoshida & Jian Feng Ma, 2017. "Reducing phosphorus accumulation in rice grains with an impaired transporter in the node," Nature, Nature, vol. 541(7635), pages 92-95, January.
    4. Takaaki Miyaji & Takashi Kuromori & Yu Takeuchi & Naoki Yamaji & Kengo Yokosho & Atsushi Shimazawa & Eriko Sugimoto & Hiroshi Omote & Jian Feng Ma & Kazuo Shinozaki & Yoshinori Moriyama, 2015. "AtPHT4;4 is a chloroplast-localized ascorbate transporter in Arabidopsis," Nature Communications, Nature, vol. 6(1), pages 1-11, May.
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