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Thalamus enables active dendritic coupling of inputs arriving at different cortical layers

Author

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  • Arco Bast

    (Max Planck Institute for Neurobiology of Behavior – caesar; Ludwig-Erhard-Allee 2
    International Max Planck Research School for Brain and Behavior; Ludwig-Erhard-Allee 2
    Howard Hughes Medical Institute)

  • Jason M. Guest

    (Max Planck Institute for Neurobiology of Behavior – caesar; Ludwig-Erhard-Allee 2
    International Max Planck Research School for Brain and Behavior; Ludwig-Erhard-Allee 2
    Jupiter)

  • Rieke Fruengel

    (Max Planck Institute for Neurobiology of Behavior – caesar; Ludwig-Erhard-Allee 2
    International Max Planck Research School for Brain and Behavior; Ludwig-Erhard-Allee 2)

  • Rajeevan T. Narayanan

    (Max Planck Institute for Neurobiology of Behavior – caesar; Ludwig-Erhard-Allee 2
    University of Düsseldorf)

  • Christiaan P. J. Kock

    (VU Amsterdam; De Boelelaan 1100)

  • Marcel Oberlaender

    (Max Planck Institute for Neurobiology of Behavior – caesar; Ludwig-Erhard-Allee 2
    VU Amsterdam; De Boelelaan 1100)

Abstract

Dendritic calcium action potentials (APs) enable the main output neurons of the cerebral cortex – pyramidal tract neurons (PTs) – to associate inputs that arrive at different cortical layers. How synaptic inputs evoke calcium APs during in vivo conditions is yet unclear. We combine in vivo recordings in male rats with synaptic input reconstructions, multi-scale modelling and optogenetic manipulations. We find that thalamocortical (TC) synapses, which provide sensory input to cortex, target specifically and most densely the dendritic domain that initiates calcium APs in PTs. Sensory input from thalamus is hence a reliable, but weak source for activating the dendritic calcium domain. Because it is fast and local, this activation enables active dendritic coupling of sensory input with multiple sensory-evoked and ongoing input streams that arrive during and surprisingly before the stimulus. This ‘TC coupling’ mechanism accounts for the modulation of the first sensory responses that leave the cortex with bursts of APs.

Suggested Citation

  • Arco Bast & Jason M. Guest & Rieke Fruengel & Rajeevan T. Narayanan & Christiaan P. J. Kock & Marcel Oberlaender, 2025. "Thalamus enables active dendritic coupling of inputs arriving at different cortical layers," Nature Communications, Nature, vol. 16(1), pages 1-19, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-64152-0
    DOI: 10.1038/s41467-025-64152-0
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    References listed on IDEAS

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    1. Ehud Ahissar & Ronen Sosnik & Sebastian Haidarliu, 2000. "Transformation from temporal to rate coding in a somatosensory thalamocortical pathway," Nature, Nature, vol. 406(6793), pages 302-306, July.
    2. Matthew E. Larkum & J. Julius Zhu & Bert Sakmann, 1999. "A new cellular mechanism for coupling inputs arriving at different cortical layers," Nature, Nature, vol. 398(6725), pages 338-341, March.
    3. Gerardo Rojas-Piloni & Jason M. Guest & Robert Egger & Andrew S. Johnson & Bert Sakmann & Marcel Oberlaender, 2017. "Relationships between structure, in vivo function and long-range axonal target of cortical pyramidal tract neurons," Nature Communications, Nature, vol. 8(1), pages 1-11, December.
    4. Ning-long Xu & Mark T. Harnett & Stephen R. Williams & Daniel Huber & Daniel H. O’Connor & Karel Svoboda & Jeffrey C. Magee, 2012. "Nonlinear dendritic integration of sensory and motor input during an active sensing task," Nature, Nature, vol. 492(7428), pages 247-251, December.
    5. Leopoldo Petreanu & Tianyi Mao & Scott M. Sternson & Karel Svoboda, 2009. "The subcellular organization of neocortical excitatory connections," Nature, Nature, vol. 457(7233), pages 1142-1145, February.
    6. Etay Hay & Sean Hill & Felix Schürmann & Henry Markram & Idan Segev, 2011. "Models of Neocortical Layer 5b Pyramidal Cells Capturing a Wide Range of Dendritic and Perisomatic Active Properties," PLOS Computational Biology, Public Library of Science, vol. 7(7), pages 1-18, July.
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