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NRC31 limits the imprinting of astrocyte epigenetic inflammatory memory early in life

Author

Listed:
  • Hong-Gyun Lee

    (Harvard Medical School
    Seoul National University)

  • Francisco J. Quintana

    (Harvard Medical School
    Broad Institute of MIT and Harvard
    Gene Lay Institute of Immunology and Inflammation)

Abstract

In a recent study, Park et al. show that early-life loss of NR3C1 in astrocytes establishes a long-lasting epigenetic memory that heightens neuroinflammation and worsens pathology in the central nervous system (CNS) later in life. These findings highlight the potential roles of astrocyte inflammatory memory in CNS pathology, as well as potential targets for its modulation.

Suggested Citation

  • Hong-Gyun Lee & Francisco J. Quintana, 2025. "NRC31 limits the imprinting of astrocyte epigenetic inflammatory memory early in life," Nature Communications, Nature, vol. 16(1), pages 1-3, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-64102-w
    DOI: 10.1038/s41467-025-64102-w
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    References listed on IDEAS

    as
    1. Seongwan Park & Hyeonji Park & Youkyeong Gloria Byun & Xiaolin Wei & Junghyun Eom & Jaegeon Joo & Andrew J. Lee & Yarui Diao & Won-Suk Chung & Inkyung Jung, 2025. "NR3C1-mediated epigenetic regulation suppresses astrocytic immune responses in mice," Nature Communications, Nature, vol. 16(1), pages 1-16, December.
    2. Hong-Gyun Lee & Joseph M. Rone & Zhaorong Li & Camilo Faust Akl & Seung Won Shin & Joon-Hyuk Lee & Lucas E. Flausino & Florian Pernin & Chun-Cheih Chao & Kilian L. Kleemann & Lena Srun & Tomer Illouz , 2024. "Author Correction: Disease-associated astrocyte epigenetic memory promotes CNS pathology," Nature, Nature, vol. 631(8020), pages 8-8, July.
    3. Kenya Honda & Dan R. Littman, 2016. "The microbiota in adaptive immune homeostasis and disease," Nature, Nature, vol. 535(7610), pages 75-84, July.
    4. Ann-Christin Wendeln & Karoline Degenhardt & Lalit Kaurani & Michael Gertig & Thomas Ulas & Gaurav Jain & Jessica Wagner & Lisa M. Häsler & Katleen Wild & Angelos Skodras & Thomas Blank & Ori Staszews, 2018. "Innate immune memory in the brain shapes neurological disease hallmarks," Nature, Nature, vol. 556(7701), pages 332-338, April.
    5. Se-In Lee & Jichang Yu & Hyein Lee & Buyun Kim & Min Jun Jang & Hyeonbin Jo & Na Yeon Kim & Malk Eun Pak & Jae Kwang Kim & Sukhee Cho & Hong-Hee Won & Min Soo Kim & Fan Gao & Younghoon Go & Jinsoo Seo, 2025. "Astrocyte priming enhances microglial Aβ clearance and is compromised by APOE4," Nature Communications, Nature, vol. 16(1), pages 1-14, December.
    6. Hong-Gyun Lee & Joseph M. Rone & Zhaorong Li & Camilo Faust Akl & Seung Won Shin & Joon-Hyuk Lee & Lucas E. Flausino & Florian Pernin & Chun-Cheih Chao & Kilian L. Kleemann & Lena Srun & Tomer Illouz , 2024. "Disease-associated astrocyte epigenetic memory promotes CNS pathology," Nature, Nature, vol. 627(8005), pages 865-872, March.
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