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ERH promotes primary microRNA processing beyond cluster assistance

Author

Listed:
  • Harim Jang

    (Institute for Basic Science
    Seoul National University)

  • Junyoung Park

    (Institute for Basic Science
    Seoul National University)

  • V. Narry Kim

    (Institute for Basic Science
    Seoul National University)

Abstract

MicroRNA (miRNA) maturation is initiated by the Microprocessor complex, comprising DROSHA and DGCR8, that processes primary miRNAs (pri-miRNAs). Recent studies have identified ERH and SAFB2 as auxiliary factors that enhance the functionality of the Microprocessor. These factors are required for cluster assistance, where optimal pri-miRNAs facilitate the processing of adjacent suboptimal pri-miRNAs. However, the specific action mechanisms of ERH and SAFB2 have not yet been defined. In this study, we found that ERH broadly enhances the processing of pri-miRNAs regardless of their genomic contexts, affecting both stand-alone and clustered ones. Suboptimal hairpins are affected more prominently by ERH knockdown than efficiently processed hairpins. In contrast, SAFB2 specifically supports the processing of suboptimal pri-miRNA hairpins within clusters. This study reveals the distinct roles of ERH and SAFB2 in cluster assistance and presents a new model, in which SAFB2 facilitates the Microprocessor’s transfer between hairpins, while ERH enables the efficient processing of suboptimal pri-miRNAs.

Suggested Citation

  • Harim Jang & Junyoung Park & V. Narry Kim, 2025. "ERH promotes primary microRNA processing beyond cluster assistance," Nature Communications, Nature, vol. 16(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-63015-y
    DOI: 10.1038/s41467-025-63015-y
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