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Microenvironment-feedback regulated hydrogels as living wound healing materials

Author

Listed:
  • Yibo Cheng

    (East China University of Science and Technology
    East China Normal University)

  • Yanwen Wang

    (Shanghai Jiao Tong University School of Medicine)

  • Yunyi Wang

    (East China Normal University)

  • Poh-Ching Tan

    (Shanghai Jiao Tong University School of Medicine)

  • Shiyun Yu

    (East China University of Science and Technology)

  • Chi Li

    (East China Normal University)

  • Zi-Yuan Li

    (East China University of Science and Technology)

  • Qing-Feng Li

    (Shanghai Jiao Tong University School of Medicine)

  • Shuang-Bai Zhou

    (Shanghai Jiao Tong University School of Medicine)

  • Chen Wang

    (East China Normal University)

  • Junji Zhang

    (East China University of Science and Technology)

  • He Tian

    (East China University of Science and Technology)

Abstract

Physiological microenvironments present a time-dependent variation during pathogenic or therapeutic processes, which call for life-like biomaterials of dynamic adaptation. However, current prevailed biomaterials maintain a passively responsive mode and lack autonomous and interactive dynamics. Striving for a paradigm of microenvironment interactive and self-regulatory medical agents as next-generation of biomaterials is of desperate need. Herein, we develop a microenvironment-feedback hydrogel as a living dressing biomaterial catering diabetic chronic wounds. This dynamic hydrogel leverages the initial alkaline pH of the wound bed as fuel and employs biocatalytic acid generation as the anti-fuel. By coupling this feedback loop to pH-regulated imine crosslinks, the hydrogel facilitates adaptive sol-gel cycling with programmable glucose oxidase (GOx) release in a Type-I diabetic mouse model. Thus, homeostatic wound pH and blood glucose levels are achieved, favoring accelerated in vivo wound healing and tissue repair.

Suggested Citation

  • Yibo Cheng & Yanwen Wang & Yunyi Wang & Poh-Ching Tan & Shiyun Yu & Chi Li & Zi-Yuan Li & Qing-Feng Li & Shuang-Bai Zhou & Chen Wang & Junji Zhang & He Tian, 2025. "Microenvironment-feedback regulated hydrogels as living wound healing materials," Nature Communications, Nature, vol. 16(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-60858-3
    DOI: 10.1038/s41467-025-60858-3
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    1. Leon Glass, 2001. "Synchronization and rhythmic processes in physiology," Nature, Nature, vol. 410(6825), pages 277-284, March.
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