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Asynchronous development of the mouse auditory cortex is driven by hemispheric identity and sex

Author

Listed:
  • Ashlan P. Reid

    (The City College of New York
    Cold Spring Harbor Laboratory)

  • Demetrios Neophytou

    (CUNY Graduate Center)

  • Robert Levy

    (The City College of New York)

  • Cody Pham

    (Washington University School of Medicine)

  • Hysell V. Oviedo

    (Washington University School of Medicine)

Abstract

Lateralized auditory processing is essential for specialized functions such as speech processing, typically dominated by the Left Auditory Cortex (ACx) in humans. Hemispheric specializations also occur in the adult mouse ACx, but their developmental origins are unclear. Our study finds that the Left and Right ACx in mice reach developmental milestones at different ages. Thalamocortical responses and maturation of synaptic dynamics develop earlier in the Right ACx than the Left. We show that this timing offset predicts hemisphere-dependent differences in sensory-driven plasticity. Juvenile tone exposure at specific times results in imbalanced adult tone frequency representations in the Right and Left ACx. Additionally, sex influences the timing of plasticity; female Right ACx plasticity occurs before male Right ACx, and female Left ACx aligns with male Right ACx plasticity. Our findings demonstrate that sex and hemispheric identity drive asynchronous development and contribute to functional differences in sensory cortices.

Suggested Citation

  • Ashlan P. Reid & Demetrios Neophytou & Robert Levy & Cody Pham & Hysell V. Oviedo, 2025. "Asynchronous development of the mouse auditory cortex is driven by hemispheric identity and sex," Nature Communications, Nature, vol. 16(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-58891-3
    DOI: 10.1038/s41467-025-58891-3
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    References listed on IDEAS

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    3. Robert B. Levy & Tiemo Marquarding & Ashlan P. Reid & Christopher M. Pun & Nicolas Renier & Hysell V. Oviedo, 2019. "Circuit asymmetries underlie functional lateralization in the mouse auditory cortex," Nature Communications, Nature, vol. 10(1), pages 1-15, December.
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