Author
Listed:
- Lior Aroeti
(The Hebrew University of Jerusalem)
- Netanel Elbaz
(The Hebrew University of Jerusalem)
- Raya Faigenbaum-Romm
(The Hebrew University of Jerusalem
The Hebrew University)
- Oren Yakovian
(The Hebrew University of Jerusalem
The Hebrew University)
- Yael Altuvia
(The Hebrew University of Jerusalem)
- Liron Argaman
(The Hebrew University of Jerusalem)
- Naama Katsowich
(The Hebrew University of Jerusalem)
- Michal Bejerano-Sagie
(The Hebrew University of Jerusalem)
- Miriam Ravins
(The Hebrew University of Jerusalem)
- Hanah Margalit
(The Hebrew University of Jerusalem)
- Sigal Ben-Yehuda
(The Hebrew University of Jerusalem)
- Ilan Rosenshine
(The Hebrew University of Jerusalem)
Abstract
The RNA-binding protein CsrA regulates the expression of hundreds of genes in several bacterial species, thus controlling virulence and other processes. However, the outcome of the CsrA-mRNA interactions is modulated by competing small RNAs and other factors through mechanisms that are only partially understood. Here, we show that CsrA accumulates in a dynamic membraneless compartment in cells of E. coli and other pathogenic species. In addition to CsrA, the compartment contains components of the RNA-degrading complex (degradosome), regulatory small RNAs, and selected mRNAs. Formation of the compartment is associated with a switch between promoting and repressing virulence gene expression by CsrA. We suggest that similar CsrA switches may be widespread in diverse bacteria.
Suggested Citation
Lior Aroeti & Netanel Elbaz & Raya Faigenbaum-Romm & Oren Yakovian & Yael Altuvia & Liron Argaman & Naama Katsowich & Michal Bejerano-Sagie & Miriam Ravins & Hanah Margalit & Sigal Ben-Yehuda & Ilan R, 2025.
"Formation of a membraneless compartment regulates bacterial virulence,"
Nature Communications, Nature, vol. 16(1), pages 1-14, December.
Handle:
RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-58829-9
DOI: 10.1038/s41467-025-58829-9
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