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An RNA-binding protein acts as a major post-transcriptional modulator in Bacillus anthracis

Author

Listed:
  • Hualiang Pi

    (Vanderbilt University Medical Center
    Vanderbilt University)

  • Andy Weiss

    (Vanderbilt University Medical Center
    Vanderbilt University)

  • Clare L. Laut

    (Vanderbilt University Medical Center
    Vanderbilt University)

  • Caroline M. Grunenwald

    (Vanderbilt University Medical Center
    Vanderbilt University)

  • Hannah K. Lin

    (Grove City College)

  • Xinjie I. Yi

    (Grove City College)

  • Devin L. Stauff

    (Grove City College)

  • Eric P. Skaar

    (Vanderbilt University Medical Center
    Vanderbilt University)

Abstract

HitRS is a two-component system that responds to cell envelope damage in the human pathogen Bacillus anthracis. Here we identify an RNA-binding protein, KrrA, that regulates HitRS function by modulating the stability of the hitRS mRNA. In addition to hitRS, KrrA binds to over 70 RNAs and, directly or indirectly, affects the expression of over 150 genes involved in multiple processes, including genetic competence, sporulation, RNA turnover, DNA repair, transport, and cellular metabolism. KrrA does not exhibit detectable nuclease activity in vitro, and thus the mechanism by which it modulates mRNA stability remains unclear.

Suggested Citation

  • Hualiang Pi & Andy Weiss & Clare L. Laut & Caroline M. Grunenwald & Hannah K. Lin & Xinjie I. Yi & Devin L. Stauff & Eric P. Skaar, 2022. "An RNA-binding protein acts as a major post-transcriptional modulator in Bacillus anthracis," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29209-4
    DOI: 10.1038/s41467-022-29209-4
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    References listed on IDEAS

    as
    1. Anastasia H. Potts & Christopher A. Vakulskas & Archana Pannuri & Helen Yakhnin & Paul Babitzke & Tony Romeo, 2017. "Global role of the bacterial post-transcriptional regulator CsrA revealed by integrated transcriptomics," Nature Communications, Nature, vol. 8(1), pages 1-15, December.
    2. Grace E. Johnson & Jean-Benoît Lalanne & Michelle L. Peters & Gene-Wei Li, 2020. "Functionally uncoupled transcription–translation in Bacillus subtilis," Nature, Nature, vol. 585(7823), pages 124-128, September.
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