Sex-specific perturbations of neuronal development caused by mutations in the autism risk gene DDX3X
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DOI: 10.1038/s41467-025-59680-8
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- Maud Borensztein & Ikuhiro Okamoto & Laurène Syx & Guillaume Guilbaud & Christel Picard & Katia Ancelin & Rafael Galupa & Patricia Diabangouaya & Nicolas Servant & Emmanuel Barillot & Azim Surani & Mi, 2017. "Contribution of epigenetic landscapes and transcription factors to X-chromosome reactivation in the inner cell mass," Nature Communications, Nature, vol. 8(1), pages 1-14, December.
- Iva Salamon & Yongkyu Park & Terezija Miškić & Janja Kopić & Paul Matteson & Nicholas F. Page & Alfonso Roque & Geoffrey W. McAuliffe & John Favate & Marta Garcia-Forn & Premal Shah & Miloš Judaš & Ja, 2023. "Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
- Silvia De Rubeis & Xin He & Arthur P. Goldberg & Christopher S. Poultney & Kaitlin Samocha & A. Ercument Cicek & Yan Kou & Li Liu & Menachem Fromer & Susan Walker & Tarjinder Singh & Lambertus Klei & , 2014. "Synaptic, transcriptional and chromatin genes disrupted in autism," Nature, Nature, vol. 515(7526), pages 209-215, November.
- Saeede Salehi & Abdolhossein Zare & Gianluca Prezza & Jakob Bader & Cornelius Schneider & Utz Fischer & Felix Meissner & Matthias Mann & Michael Briese & Michael Sendtner, 2023. "Cytosolic Ptbp2 modulates axon growth in motoneurons through axonal localization and translation of Hnrnpr," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
- Yuan Mei & Patricia Monteiro & Yang Zhou & Jin-Ah Kim & Xian Gao & Zhanyan Fu & Guoping Feng, 2016. "Adult restoration of Shank3 expression rescues selective autistic-like phenotypes," Nature, Nature, vol. 530(7591), pages 481-484, February.
- Yehezkel Sztainberg & Hong-mei Chen & John W. Swann & Shuang Hao & Bin Tang & Zhenyu Wu & Jianrong Tang & Ying-Wooi Wan & Zhandong Liu & Frank Rigo & Huda Y. Zoghbi, 2015. "Reversal of phenotypes in MECP2 duplication mice using genetic rescue or antisense oligonucleotides," Nature, Nature, vol. 528(7580), pages 123-126, December.
- Martin A. Mensah & Henri Niskanen & Alexandre P. Magalhaes & Shaon Basu & Martin Kircher & Henrike L. Sczakiel & Alisa M. V. Reiter & Jonas Elsner & Peter Meinecke & Saskia Biskup & Brian H. Y. Chung , 2023. "Aberrant phase separation and nucleolar dysfunction in rare genetic diseases," Nature, Nature, vol. 614(7948), pages 564-571, February.
- Ekaterina Borisova & Andrew G. Newman & Marta Couce Iglesias & Rike Dannenberg & Theres Schaub & Bo Qin & Alexandra Rusanova & Marisa Brockmann & Janina Koch & Marieatou Daniels & Paul Turko & Olaf Ja, 2024. "Protein translation rate determines neocortical neuron fate," Nature Communications, Nature, vol. 15(1), pages 1-25, December.
- Yuki Toyama & Ichio Shimada, 2024. "NMR characterization of RNA binding property of the DEAD-box RNA helicase DDX3X and its implications for helicase activity," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
- Sang S. Seo & Susana R. Louros & Natasha Anstey & Miguel A. Gonzalez-Lozano & Callista B. Harper & Nicholas C. Verity & Owen Dando & Sophie R. Thomson & Jennifer C. Darnell & Peter C. Kind & Ka Wan Li, 2022. "Excess ribosomal protein production unbalances translation in a model of Fragile X Syndrome," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
- Konrad J. Karczewski & Laurent C. Francioli & Grace Tiao & Beryl B. Cummings & Jessica Alföldi & Qingbo Wang & Ryan L. Collins & Kristen M. Laricchia & Andrea Ganna & Daniel P. Birnbaum & Laura D. Gau, 2020. "The mutational constraint spectrum quantified from variation in 141,456 humans," Nature, Nature, vol. 581(7809), pages 434-443, May.
- Taru Tukiainen & Alexandra-Chloé Villani & Angela Yen & Manuel A. Rivas & Jamie L. Marshall & Rahul Satija & Matt Aguirre & Laura Gauthier & Mark Fleharty & Andrew Kirby & Beryl B. Cummings & Stephane, 2017. "Landscape of X chromosome inactivation across human tissues," Nature, Nature, vol. 550(7675), pages 244-248, October.
- Christoph Leidig & Matthias Thoms & Iris Holdermann & Bettina Bradatsch & Otto Berninghausen & Gert Bange & Irmgard Sinning & Ed Hurt & Roland Beckmann, 2014. "60S ribosome biogenesis requires rotation of the 5S ribonucleoprotein particle," Nature Communications, Nature, vol. 5(1), pages 1-8, May.
- Claudia M. Fusco & Kristina Desch & Aline R. Dörrbaum & Mantian Wang & Anja Staab & Ivy C. W. Chan & Eleanor Vail & Veronica Villeri & Julian D. Langer & Erin M. Schuman, 2021. "Neuronal ribosomes exhibit dynamic and context-dependent exchange of ribosomal proteins," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
- Maria Hondele & Ruchika Sachdev & Stephanie Heinrich & Juan Wang & Pascal Vallotton & Beatriz M. A. Fontoura & Karsten Weis, 2019. "DEAD-box ATPases are global regulators of phase-separated organelles," Nature, Nature, vol. 573(7772), pages 144-148, September.
- Diego Cortez & Ray Marin & Deborah Toledo-Flores & Laure Froidevaux & Angélica Liechti & Paul D. Waters & Frank Grützner & Henrik Kaessmann, 2014. "Origins and functional evolution of Y chromosomes across mammals," Nature, Nature, vol. 508(7497), pages 488-493, April.
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