IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v16y2025i1d10.1038_s41467-025-58469-z.html
   My bibliography  Save this article

Photocatalytic deoxygenative Z-selective olefination of aliphatic alcohols

Author

Listed:
  • Sai Rohini Narayanan Kolusu

    (s/n)

  • Irene Sánchez-Sordo

    (s/n)

  • Carla Aira-Rodríguez

    (s/n)

  • Emanuele Azzi

    (s/n)

  • Manuel Nappi

    (s/n)

Abstract

Alcohols are one of the most abundant functional groups in commercially available materials and biologically active compounds. Herein, we report a metal-free photocatalytic method for the deoxygenative Z-selective olefination of aliphatic alcohols. Key to this methodology is the radical olefination and isomerization of unstabilized open-shell species generated in situ by a catalytic reductive scission of benzoate esters. These processes are simultaneously orchestrated by a single phenothiazine photocatalyst via singlet and triplet excited states. Our protocol is distinguished by its wide substrate scope and broad applicability, even in the context of pharmaceuticals and saccharides. Given the mild and water-compatible conditions, our chemistry can also be utilized to functionalize DNA headpieces for DELs applications.

Suggested Citation

  • Sai Rohini Narayanan Kolusu & Irene Sánchez-Sordo & Carla Aira-Rodríguez & Emanuele Azzi & Manuel Nappi, 2025. "Photocatalytic deoxygenative Z-selective olefination of aliphatic alcohols," Nature Communications, Nature, vol. 16(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-58469-z
    DOI: 10.1038/s41467-025-58469-z
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-025-58469-z
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-025-58469-z?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Zhe Dong & David W. C. MacMillan, 2021. "Metallaphotoredox-enabled deoxygenative arylation of alcohols," Nature, Nature, vol. 598(7881), pages 451-456, October.
    2. Jian Jin & David W. C. MacMillan, 2015. "Alcohols as alkylating agents in heteroarene C–H functionalization," Nature, Nature, vol. 525(7567), pages 87-90, September.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Yue Wang & Suping Zhang & Ke Zeng & Pengli Zhang & Xiaorong Song & Tie-Gen Chen & Guoqin Xia, 2024. "Deoxygenative radical cross-coupling of C(sp3)−O/C(sp3)−H bonds promoted by hydrogen-bond interaction," Nature Communications, Nature, vol. 15(1), pages 1-8, December.
    2. Kenta Yokoi & Hans Renata, 2025. "Enantioselective total synthesis of lycoposerramine congeners through late-stage nitrogen deletion," Nature Communications, Nature, vol. 16(1), pages 1-7, December.
    3. Li-Li Zhang & Yu-Zhong Gao & Sheng-Han Cai & Hui Yu & Shou-Jie Shen & Qian Ping & Ze-Peng Yang, 2024. "Ni-catalyzed enantioconvergent deoxygenative reductive cross-coupling of unactivated alkyl alcohols and aryl bromides," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    4. Hao Yang & Jinhui Xu & Hui Cao & Jie Wu & Dan Zhao, 2023. "Recovery of homogeneous photocatalysts by covalent organic framework membranes," Nature Communications, Nature, vol. 14(1), pages 1-10, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-58469-z. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.