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Fe-electrocatalytic deoxygenative Giese reaction

Author

Listed:
  • Longhui Yu

    (Clear Water Bay)

  • Shangzhao Li

    (Clear Water Bay)

  • Hiroshige Ogawa

    (Clear Water Bay)

  • Yilin Ma

    (Clear Water Bay)

  • Qing Chen

    (Clear Water Bay)

  • Ken Yamazaki

    (Tsushimanaka)

  • Yuuya Nagata

    (Hokkaido University
    Tsukuba)

  • Hugh Nakamura

    (Clear Water Bay)

Abstract

A redox-neutral Fe-electrocatalytic deoxygenative Giese reaction is reported. Hydroxyl groups are among the most abundant functional groups, and thus, the development of efficient reactions for their conversion has significant importance in medicinal and process chemistry. Here, we present a redox-neutral Giese reaction via anodic oxidation to generate phosphonium ions in combination with a cathodic reduction to yield low-valent Fe-catalysts. This reaction represents a promising example of a redox-neutral reaction using an Fe-catalyst and electrochemistry. The results obtained in this study will facilitate the exploration of a wide range of novel reactions employing this redox cycle in the future.

Suggested Citation

  • Longhui Yu & Shangzhao Li & Hiroshige Ogawa & Yilin Ma & Qing Chen & Ken Yamazaki & Yuuya Nagata & Hugh Nakamura, 2025. "Fe-electrocatalytic deoxygenative Giese reaction," Nature Communications, Nature, vol. 16(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-63515-x
    DOI: 10.1038/s41467-025-63515-x
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    References listed on IDEAS

    as
    1. Wen Zhang & Lingxiang Lu & Wendy Zhang & Yi Wang & Skyler D. Ware & Jose Mondragon & Jonas Rein & Neil Strotman & Dan Lehnherr & Kimberly A. See & Song Lin, 2022. "Electrochemically driven cross-electrophile coupling of alkyl halides," Nature, Nature, vol. 604(7905), pages 292-297, April.
    2. Zhe Dong & David W. C. MacMillan, 2021. "Metallaphotoredox-enabled deoxygenative arylation of alcohols," Nature, Nature, vol. 598(7881), pages 451-456, October.
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