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Quasi Fe MIL-53 nanozyme inducing ferroptosis and immunogenic cell death for cancer immunotherapy

Author

Listed:
  • Zihui Yan

    (Changzhou University)

  • Yang Bai

    (Changzhou University)

  • Songtao Zhang

    (Yangzhou University)

  • Lingyi Kong

    (Nanjing Normal University)

  • Yu Wang

    (Nanjing Normal University)

  • Huilin Sun

    (Changzhou University)

  • Yi Li

    (Changzhou University)

  • Lin Qiu

    (Changzhou University)

  • Ruijie Zhang

    (Changzhou University)

  • Pengju Jiang

    (Changzhou University)

  • Donghui Zhao

    (Changzhou University)

  • Zhongyan Chen

    (Wenzhou University)

  • Yafei Li

    (Changzhou University
    Nanjing Normal University)

  • Huan Pang

    (Yangzhou University)

  • Jianhao Wang

    (Changzhou University
    Changzhou University)

Abstract

Nanozymes offer diverse therapeutic potentials for cancer treatment which is dependent on the development of nanomaterials. Quasi-metal-organic framework is a class of metal-organic framework-derived nanomaterials with a transition state from metal-organic frameworks towards metal oxide featuring porous structure and high activity. Herein an iron-based quasi-metal-organic framework nanozyme Q-MIL-53(Fe) is reported via a controlled deligandation strategy, exhibiting enhanced peroxidase-/catalase-mimic activity and glutathione depletion capacity, whose underlying mechanisms are studied via density functional theory calculations. Q-MIL-53(Fe) demonstrates biocompatibility and superior antitumor efficacy compared to pristine MIL-53(Fe). It can activate antitumor immune response by inducing ferroptosis and immunogenic cell death, promoting dendritic cell maturation and T lymphocytes infiltration. Furthermore, a combination of Q-MIL-53(Fe) and programmed cell death protein 1 antibody amplifies cancer immunotherapy. This study validates the antitumor activity of quasi-metal-organic frameworks and its immunotherapy induction potential. It would broaden the application of quasi-metal-organic frameworks and open avenues for developing antitumor nanozymes.

Suggested Citation

  • Zihui Yan & Yang Bai & Songtao Zhang & Lingyi Kong & Yu Wang & Huilin Sun & Yi Li & Lin Qiu & Ruijie Zhang & Pengju Jiang & Donghui Zhao & Zhongyan Chen & Yafei Li & Huan Pang & Jianhao Wang, 2025. "Quasi Fe MIL-53 nanozyme inducing ferroptosis and immunogenic cell death for cancer immunotherapy," Nature Communications, Nature, vol. 16(1), pages 1-19, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-57542-x
    DOI: 10.1038/s41467-025-57542-x
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    References listed on IDEAS

    as
    1. Zhusheng Huang & Yuxiang Wang & Dan Yao & Jinhui Wu & Yiqiao Hu & Ahu Yuan, 2021. "Nanoscale coordination polymers induce immunogenic cell death by amplifying radiation therapy mediated oxidative stress," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    2. Kai Cheng & Bo Liu & Xiao-Shuai Zhang & Ruo-Yun Zhang & Fang Zhang & Ghazal Ashraf & Guo-Qing Fan & Ming-Yu Tian & Xing Sun & Jing Yuan & Yuan-Di Zhao, 2022. "Biomimetic material degradation for synergistic enhanced therapy by regulating endogenous energy metabolism imaging under hypothermia," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
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