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Biomimetic material degradation for synergistic enhanced therapy by regulating endogenous energy metabolism imaging under hypothermia

Author

Listed:
  • Kai Cheng

    (Huazhong University of Science and Technology)

  • Bo Liu

    (Huazhong University of Science and Technology)

  • Xiao-Shuai Zhang

    (Huazhong University of Science and Technology)

  • Ruo-Yun Zhang

    (Huazhong University of Science and Technology)

  • Fang Zhang

    (Huazhong University of Science and Technology)

  • Ghazal Ashraf

    (Huazhong University of Science and Technology)

  • Guo-Qing Fan

    (Huazhong University of Science and Technology)

  • Ming-Yu Tian

    (Huazhong University of Science and Technology)

  • Xing Sun

    (Huazhong University of Science and Technology)

  • Jing Yuan

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Yuan-Di Zhao

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

Abstract

Inefficient tumour treatment approaches often cause fatal tumour metastases. Here, we report a biomimetic multifunctional nanoplatform explicitly engineered with a Co-based metal organic framework polydopamine heterostructure (MOF-PDA), anethole trithione (ADT), and a macrophage membrane. Co-MOF degradation in the tumour microenvironment releases Co2+, which results in the downregulation of HSP90 expression and the inhibition of cellular heat resistance, thereby improving the photothermal therapy effect of PDA. H2S secretion after the enzymatic hydrolysis of ADT leads to high-concentration gas therapy. Moreover, ADT changes the balance between nicotinamide adenine dinucleotide/flavin adenine dinucleotide (NADH/FAD) during tumour glycolysis. ATP synthesis is limited by NADH consumption, which triggers a certain degree of tumour growth inhibition and results in starvation therapy. Potentiated 2D/3D autofluorescence imaging of NADH/FAD is also achieved in liquid nitrogen and employed to efficiently monitor tumour therapy. The developed biomimetic nanoplatform provides an approach to treat orthotopic tumours and inhibit metastasis.

Suggested Citation

  • Kai Cheng & Bo Liu & Xiao-Shuai Zhang & Ruo-Yun Zhang & Fang Zhang & Ghazal Ashraf & Guo-Qing Fan & Ming-Yu Tian & Xing Sun & Jing Yuan & Yuan-Di Zhao, 2022. "Biomimetic material degradation for synergistic enhanced therapy by regulating endogenous energy metabolism imaging under hypothermia," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32349-2
    DOI: 10.1038/s41467-022-32349-2
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    References listed on IDEAS

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    1. Ru Li & Yujie Huang & Jun Lin, 2020. "Distinct effects of general anesthetics on lung metastasis mediated by IL-6/JAK/STAT3 pathway in mouse models," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    2. Thomas A. Wynn & Ajay Chawla & Jeffrey W. Pollard, 2013. "Macrophage biology in development, homeostasis and disease," Nature, Nature, vol. 496(7446), pages 445-455, April.
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