IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v16y2025i1d10.1038_s41467-025-56527-0.html
   My bibliography  Save this article

Unlocking the potential of engineered immune cell therapy for solid tumors

Author

Listed:
  • Víctor Albarrán-Fernández

    (Hospital Clínic
    August Pi I Sunyer Biomedical Research Institute (IDIBAPS))

  • Laura Angelats

    (Hospital Clínic
    August Pi I Sunyer Biomedical Research Institute (IDIBAPS))

  • Julio Delgado

    (Hospital Clínic
    University of Barcelona)

  • Alena Gros

    (Vall d’Hebron Hospital Campus)

  • Álvaro Urbano-Ispizua

    (Hospital Clínic
    University of Barcelona)

  • Sònia Guedan

    (August Pi I Sunyer Biomedical Research Institute (IDIBAPS))

  • Aleix Prat

    (Hospital Clínic
    August Pi I Sunyer Biomedical Research Institute (IDIBAPS)
    University of Barcelona
    Reveal Genomics)

Abstract

Adoptive cell therapy has emerged as a promising approach for treating advanced solid malignancies. Genetic engineering techniques represent an exciting area of research for the development of cellular products with enhanced cytotoxicity, phenotype, and metabolism.

Suggested Citation

  • Víctor Albarrán-Fernández & Laura Angelats & Julio Delgado & Alena Gros & Álvaro Urbano-Ispizua & Sònia Guedan & Aleix Prat, 2025. "Unlocking the potential of engineered immune cell therapy for solid tumors," Nature Communications, Nature, vol. 16(1), pages 1-5, December.
  • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-56527-0
    DOI: 10.1038/s41467-025-56527-0
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-025-56527-0
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-025-56527-0?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Rachel C. Lynn & Evan W. Weber & Elena Sotillo & David Gennert & Peng Xu & Zinaida Good & Hima Anbunathan & John Lattin & Robert Jones & Victor Tieu & Surya Nagaraja & Jeffrey Granja & Charles F. A. B, 2019. "c-Jun overexpression in CAR T cells induces exhaustion resistance," Nature, Nature, vol. 576(7786), pages 293-300, December.
    2. Julia Carnevale & Eric Shifrut & Nupura Kale & William A. Nyberg & Franziska Blaeschke & Yan Yi Chen & Zhongmei Li & Sagar P. Bapat & Morgan E. Diolaiti & Patrick O’Leary & Shane Vedova & Julia Belk &, 2022. "RASA2 ablation in T cells boosts antigen sensitivity and long-term function," Nature, Nature, vol. 609(7925), pages 174-182, September.
    3. Lauren Giuffrida & Kevin Sek & Melissa A. Henderson & Junyun Lai & Amanda X. Y. Chen & Deborah Meyran & Kirsten L. Todd & Emma V. Petley & Sherly Mardiana & Christina Mølck & Gregory D. Stewart & Benj, 2021. "CRISPR/Cas9 mediated deletion of the adenosine A2A receptor enhances CAR T cell efficacy," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    4. Jack D. Chan & Christina M. Scheffler & Isabelle Munoz & Kevin Sek & Joel N. Lee & Yu-Kuan Huang & Kah Min Yap & Nicole Y. L. Saw & Jasmine Li & Amanda X. Y. Chen & Cheok Weng Chan & Emily B. Derrick , 2024. "FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy," Nature, Nature, vol. 629(8010), pages 201-210, May.
    5. Omar Khan & Josephine R. Giles & Sierra McDonald & Sasikanth Manne & Shin Foong Ngiow & Kunal P. Patel & Michael T. Werner & Alexander C. Huang & Katherine A. Alexander & Jennifer E. Wu & John Attanas, 2019. "TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion," Nature, Nature, vol. 571(7764), pages 211-218, July.
    6. Irene Andreu-Saumell & Alba Rodriguez-Garcia & Vanessa Mühlgrabner & Marta Gimenez-Alejandre & Berta Marzal & Joan Castellsagué & Fara Brasó-Maristany & Hugo Calderon & Laura Angelats & Salut Colell &, 2024. "CAR affinity modulates the sensitivity of CAR-T cells to PD-1/PD-L1-mediated inhibition," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    7. Jun Wei & Lingyun Long & Wenting Zheng & Yogesh Dhungana & Seon Ah Lim & Cliff Guy & Yanyan Wang & Yong-Dong Wang & Chenxi Qian & Beisi Xu & Anil KC & Jordy Saravia & Hongling Huang & Jiyang Yu & John, 2019. "Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy," Nature, Nature, vol. 576(7787), pages 471-476, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Xiaofeng Liao & Wenxue Li & Hongyue Zhou & Barani Kumar Rajendran & Ao Li & Jingjing Ren & Yi Luan & David A. Calderwood & Benjamin Turk & Wenwen Tang & Yansheng Liu & Dianqing Wu, 2024. "The CUL5 E3 ligase complex negatively regulates central signaling pathways in CD8+ T cells," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    2. Carli M. Stewart & Elizabeth L. Siegler & R. Leo Sakemura & Michelle J. Cox & Truc Huynh & Brooke Kimball & Long Mai & Ismail Can & Claudia Manriquez Roman & Kun Yun & Olivia Sirpilla & James H. Girsc, 2024. "IL-4 drives exhaustion of CD8+ CART cells," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    3. Hideki Ogura & Jin Gohda & Xiuyuan Lu & Mizuki Yamamoto & Yoshio Takesue & Aoi Son & Sadayuki Doi & Kazuyuki Matsushita & Fumitaka Isobe & Yoshihiro Fukuda & Tai-Ping Huang & Takamasa Ueno & Naomi Mam, 2022. "Dysfunctional Sars-CoV-2-M protein-specific cytotoxic T lymphocytes in patients recovering from severe COVID-19," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    4. Feng Xie & Xiaoxue Zhou & Peng Su & Heyu Li & Yifei Tu & Jinjin Du & Chen Pan & Xiang Wei & Min Zheng & Ke Jin & Liyan Miao & Chao Wang & Xuli Meng & Hans Dam & Peter Dijke & Long Zhang & Fangfang Zho, 2022. "Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    5. Moujtaba Y. Kasmani & Paytsar Topchyan & Ashley K. Brown & Ryan J. Brown & Xiaopeng Wu & Yao Chen & Achia Khatun & Donia Alson & Yue Wu & Robert Burns & Chien-Wei Lin & Matthew R. Kudek & Jie Sun & We, 2023. "A spatial sequencing atlas of age-induced changes in the lung during influenza infection," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    6. Raymond Hall Yip Louie & Curtis Cai & Jerome Samir & Mandeep Singh & Ira W. Deveson & James M. Ferguson & Timothy G. Amos & Helen Marie McGuire & Kavitha Gowrishankar & Thiruni Adikari & Robert Balder, 2023. "CAR+ and CAR− T cells share a differentiation trajectory into an NK-like subset after CD19 CAR T cell infusion in patients with B cell malignancies," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    7. Siqi Chen & Yingyu Wang & Jessica Dang & Nuozi Song & Xiaoxin Chen & Jinhui Wang & Guo N. Huang & Christine E. Brown & Jianhua Yu & Irving L. Weissman & Steven T. Rosen & Mingye Feng, 2025. "CAR macrophages with built-In CD47 blocker combat tumor antigen heterogeneity and activate T cells via cross-presentation," Nature Communications, Nature, vol. 16(1), pages 1-20, December.
    8. Hao Wu & Xiufeng Zhao & Sophia M. Hochrein & Miriam Eckstein & Gabriela F. Gubert & Konrad Knöpper & Ana Maria Mansilla & Arman Öner & Remi Doucet-Ladevèze & Werner Schmitz & Bart Ghesquière & Sebasti, 2023. "Mitochondrial dysfunction promotes the transition of precursor to terminally exhausted T cells through HIF-1α-mediated glycolytic reprogramming," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    9. Yoshitaka Adachi & Seitaro Terakura & Masahide Osaki & Yusuke Okuno & Yoshitaka Sato & Ken Sagou & Yuki Takeuchi & Hirofumi Yokota & Kanae Imai & Peter Steinberger & Judith Leitner & Ryo Hanajiri & Ma, 2024. "Cullin-5 deficiency promotes chimeric antigen receptor T cell effector functions potentially via the modulation of JAK/STAT signaling pathway," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    10. Veronika Bandara & Jade Foeng & Batjargal Gundsambuu & Todd S. Norton & Silvana Napoli & Dylan J. McPeake & Timona S. Tyllis & Elaheh Rohani-Rad & Caitlin Abbott & Stuart J. Mills & Lih Y. Tan & Emma , 2023. "Pre-clinical validation of a pan-cancer CAR-T cell immunotherapy targeting nfP2X7," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    11. Emily N. Neubert & Julia M. DeRogatis & Sloan A. Lewis & Karla M. Viramontes & Pedro Ortega & Monique L. Henriquez & Rémi Buisson & Ilhem Messaoudi & Roberto Tinoco, 2023. "HMGB2 regulates the differentiation and stemness of exhausted CD8+ T cells during chronic viral infection and cancer," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    12. Kateryna Onyshchenko & Ren Luo & Elena Guffart & Simone Gaedicke & Anca-Ligia Grosu & Elke Firat & Gabriele Niedermann, 2023. "Expansion of circulating stem-like CD8+ T cells by adding CD122-directed IL-2 complexes to radiation and anti-PD1 therapies in mice," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    13. William H. Tomaszewski & Jessica Waibl-Polania & Molly Chakraborty & Jonathan Perera & Jeremy Ratiu & Alexandra Miggelbrink & Donald P. McDonnell & Mustafa Khasraw & David M. Ashley & Peter E. Fecci &, 2022. "Neuronal CaMKK2 promotes immunosuppression and checkpoint blockade resistance in glioblastoma," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    14. Shiyu Zuo & Chuo Li & Xiaolei Sun & Biping Deng & Yibing Zhang & Yajing Han & Zhuojun Ling & Jinlong Xu & Jiajia Duan & Zelin Wang & Xinjian Yu & Qinlong Zheng & Xiuwen Xu & Jiao Zong & Zhenglong Tian, 2024. "C-JUN overexpressing CAR-T cells in acute myeloid leukemia: preclinical characterization and phase I trial," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    15. Yufeng Wang & David L. Drum & Ruochuan Sun & Yida Zhang & Feng Chen & Fengfei Sun & Emre Dal & Ling Yu & Jingyu Jia & Shahrzad Arya & Lin Jia & Song Fan & Steven J. Isakoff & Allison M. Kehlmann & Gia, 2023. "Stressed target cancer cells drive nongenetic reprogramming of CAR T cells and solid tumor microenvironment," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    16. Aurélie Durand & Nelly Bonilla & Théo Level & Zoé Ginestet & Amélie Lombès & Vincent Guichard & Mathieu Germain & Sébastien Jacques & Franck Letourneur & Marcio Cruzeiro & Carmen Marchiol & Gilles Ren, 2024. "Type 1 interferons and Foxo1 down-regulation play a key role in age-related T-cell exhaustion in mice," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    17. Yi Liu & Brian Debo & Mingfeng Li & Zhennan Shi & Wanqiang Sheng & Yang Shi, 2021. "LSD1 inhibition sustains T cell invigoration with a durable response to PD-1 blockade," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    18. Leticia Laura Niborski & Paul Gueguen & Mengliang Ye & Allan Thiolat & Rodrigo Nalio Ramos & Pamela Caudana & Jordan Denizeau & Ludovic Colombeau & Raphaël Rodriguez & Christel Goudot & Jean-Michel Lu, 2022. "CD8+T cell responsiveness to anti-PD-1 is epigenetically regulated by Suv39h1 in melanomas," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    19. Julie Noguerol & Karl Laviolette & Margot Zahm & Adeline Chaubet & Ambrine Sahal & Claire Détraves & Romain Torres & Clothilde Demont & Véronique Adoue & Carine Joffre & Florence Cammas & Joost PM Mee, 2025. "Heterochromatic gene silencing controls CD4+ T cell susceptibility to regulatory T cell-mediated suppression in a murine allograft model," Nature Communications, Nature, vol. 16(1), pages 1-18, December.
    20. Tereza Dvorakova & Veronica Finisguerra & Matteo Formenti & Axelle Loriot & Loubna Boudhan & Jingjing Zhu & Benoit J. Van den Eynde, 2024. "Enhanced tumor response to adoptive T cell therapy with PHD2/3-deficient CD8 T cells," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-56527-0. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.