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Unlocking the potential of engineered immune cell therapy for solid tumors

Author

Listed:
  • Víctor Albarrán-Fernández

    (Hospital Clínic
    August Pi I Sunyer Biomedical Research Institute (IDIBAPS))

  • Laura Angelats

    (Hospital Clínic
    August Pi I Sunyer Biomedical Research Institute (IDIBAPS))

  • Julio Delgado

    (Hospital Clínic
    University of Barcelona)

  • Alena Gros

    (Vall d’Hebron Hospital Campus)

  • Álvaro Urbano-Ispizua

    (Hospital Clínic
    University of Barcelona)

  • Sònia Guedan

    (August Pi I Sunyer Biomedical Research Institute (IDIBAPS))

  • Aleix Prat

    (Hospital Clínic
    August Pi I Sunyer Biomedical Research Institute (IDIBAPS)
    University of Barcelona
    Reveal Genomics)

Abstract

Adoptive cell therapy has emerged as a promising approach for treating advanced solid malignancies. Genetic engineering techniques represent an exciting area of research for the development of cellular products with enhanced cytotoxicity, phenotype, and metabolism.

Suggested Citation

  • Víctor Albarrán-Fernández & Laura Angelats & Julio Delgado & Alena Gros & Álvaro Urbano-Ispizua & Sònia Guedan & Aleix Prat, 2025. "Unlocking the potential of engineered immune cell therapy for solid tumors," Nature Communications, Nature, vol. 16(1), pages 1-5, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-56527-0
    DOI: 10.1038/s41467-025-56527-0
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    1. Rachel C. Lynn & Evan W. Weber & Elena Sotillo & David Gennert & Peng Xu & Zinaida Good & Hima Anbunathan & John Lattin & Robert Jones & Victor Tieu & Surya Nagaraja & Jeffrey Granja & Charles F. A. B, 2019. "c-Jun overexpression in CAR T cells induces exhaustion resistance," Nature, Nature, vol. 576(7786), pages 293-300, December.
    2. Julia Carnevale & Eric Shifrut & Nupura Kale & William A. Nyberg & Franziska Blaeschke & Yan Yi Chen & Zhongmei Li & Sagar P. Bapat & Morgan E. Diolaiti & Patrick O’Leary & Shane Vedova & Julia Belk &, 2022. "RASA2 ablation in T cells boosts antigen sensitivity and long-term function," Nature, Nature, vol. 609(7925), pages 174-182, September.
    3. Omar Khan & Josephine R. Giles & Sierra McDonald & Sasikanth Manne & Shin Foong Ngiow & Kunal P. Patel & Michael T. Werner & Alexander C. Huang & Katherine A. Alexander & Jennifer E. Wu & John Attanas, 2019. "TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion," Nature, Nature, vol. 571(7764), pages 211-218, July.
    4. Irene Andreu-Saumell & Alba Rodriguez-Garcia & Vanessa Mühlgrabner & Marta Gimenez-Alejandre & Berta Marzal & Joan Castellsagué & Fara Brasó-Maristany & Hugo Calderon & Laura Angelats & Salut Colell &, 2024. "CAR affinity modulates the sensitivity of CAR-T cells to PD-1/PD-L1-mediated inhibition," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    5. Jun Wei & Lingyun Long & Wenting Zheng & Yogesh Dhungana & Seon Ah Lim & Cliff Guy & Yanyan Wang & Yong-Dong Wang & Chenxi Qian & Beisi Xu & Anil KC & Jordy Saravia & Hongling Huang & Jiyang Yu & John, 2019. "Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy," Nature, Nature, vol. 576(7787), pages 471-476, December.
    6. Lauren Giuffrida & Kevin Sek & Melissa A. Henderson & Junyun Lai & Amanda X. Y. Chen & Deborah Meyran & Kirsten L. Todd & Emma V. Petley & Sherly Mardiana & Christina Mølck & Gregory D. Stewart & Benj, 2021. "CRISPR/Cas9 mediated deletion of the adenosine A2A receptor enhances CAR T cell efficacy," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    7. Jack D. Chan & Christina M. Scheffler & Isabelle Munoz & Kevin Sek & Joel N. Lee & Yu-Kuan Huang & Kah Min Yap & Nicole Y. L. Saw & Jasmine Li & Amanda X. Y. Chen & Cheok Weng Chan & Emily B. Derrick , 2024. "FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy," Nature, Nature, vol. 629(8010), pages 201-210, May.
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