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Motility of an autonomous protein-based artificial motor that operates via a burnt-bridge principle

Author

Listed:
  • Chapin S. Korosec

    (Simon Fraser University
    York University)

  • Ivan N. Unksov

    (Lund University)

  • Pradheebha Surendiran

    (Lund University)

  • Roman Lyttleton

    (Lund University)

  • Paul M. G. Curmi

    (University of New South Wales)

  • Christopher N. Angstmann

    (University of New South Wales)

  • Ralf Eichhorn

    (Nordita, Royal Institute of Technology and Stockholm University)

  • Heiner Linke

    (Lund University)

  • Nancy R. Forde

    (Simon Fraser University)

Abstract

Inspired by biology, great progress has been made in creating artificial molecular motors. However, the dream of harnessing proteins – the building blocks selected by nature – to design autonomous motors has so far remained elusive. Here we report the synthesis and characterization of the Lawnmower, an autonomous, protein-based artificial molecular motor comprised of a spherical hub decorated with proteases. Its “burnt-bridge” motion is directed by cleavage of a peptide lawn, promoting motion towards unvisited substrate. We find that Lawnmowers exhibit directional motion with average speeds of up to 80 nm/s, comparable to biological motors. By selectively patterning the peptide lawn on microfabricated tracks, we furthermore show that the Lawnmower is capable of track-guided motion. Our work opens an avenue towards nanotechnology applications of artificial protein motors.

Suggested Citation

  • Chapin S. Korosec & Ivan N. Unksov & Pradheebha Surendiran & Roman Lyttleton & Paul M. G. Curmi & Christopher N. Angstmann & Ralf Eichhorn & Heiner Linke & Nancy R. Forde, 2024. "Motility of an autonomous protein-based artificial motor that operates via a burnt-bridge principle," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45570-y
    DOI: 10.1038/s41467-024-45570-y
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