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DPPIV+ fibro-adipogenic progenitors form the niche of adult skeletal muscle self-renewing resident macrophages

Author

Listed:
  • Farshad Babaeijandaghi

    (University of British Columbia
    Altos Labs Inc)

  • Nasim Kajabadi

    (University of British Columbia)

  • Reece Long

    (University of British Columbia)

  • Lin Wei Tung

    (University of British Columbia)

  • Chun Wai Cheung

    (University of British Columbia)

  • Morten Ritso

    (University of British Columbia)

  • Chih-Kai Chang

    (University of British Columbia)

  • Ryan Cheng

    (University of British Columbia)

  • Tiffany Huang

    (University of British Columbia)

  • Elena Groppa

    (University of British Columbia)

  • Jean X. Jiang

    (University of Texas Health Science Center)

  • Fabio M. V. Rossi

    (University of British Columbia)

Abstract

Adult tissue-resident macrophages (RMs) are either maintained by blood monocytes or through self-renewal. While the presence of a nurturing niche is likely crucial to support the survival and function of self-renewing RMs, evidence regarding its nature is limited. Here, we identify fibro-adipogenic progenitors (FAPs) as the main source of colony-stimulating factor 1 (CSF1) in resting skeletal muscle. Using parabiosis in combination with FAP-deficient transgenic mice (PdgfrαCreERT2 × DTA) or mice lacking FAP-derived CSF1 (PdgfrαCreERT2 × Csf1flox/null), we show that local CSF1 from FAPs is required for the survival of both TIM4- monocyte-derived and TIM4+ self-renewing RMs in adult skeletal muscle. The spatial distribution and number of TIM4+ RMs coincide with those of dipeptidyl peptidase IV (DPPIV)+ FAPs, suggesting their role as CSF1-producing niche cells for self-renewing RMs. This finding identifies opportunities to precisely manipulate the function of self-renewing RMs in situ to further unravel their role in health and disease.

Suggested Citation

  • Farshad Babaeijandaghi & Nasim Kajabadi & Reece Long & Lin Wei Tung & Chun Wai Cheung & Morten Ritso & Chih-Kai Chang & Ryan Cheng & Tiffany Huang & Elena Groppa & Jean X. Jiang & Fabio M. V. Rossi, 2023. "DPPIV+ fibro-adipogenic progenitors form the niche of adult skeletal muscle self-renewing resident macrophages," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43579-3
    DOI: 10.1038/s41467-023-43579-3
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    References listed on IDEAS

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    1. Masako Kohyama & Wataru Ise & Brian T. Edelson & Peter R. Wilker & Kai Hildner & Carlo Mejia & William A. Frazier & Theresa L. Murphy & Kenneth M. Murphy, 2009. "Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis," Nature, Nature, vol. 457(7227), pages 318-321, January.
    2. David T. Scadden, 2006. "The stem-cell niche as an entity of action," Nature, Nature, vol. 441(7097), pages 1075-1079, June.
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