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Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis

Author

Listed:
  • Masako Kohyama

    (Department of Pathology and Immunology,
    Howard Hughes Medical Institute,)

  • Wataru Ise

    (Department of Pathology and Immunology,
    Howard Hughes Medical Institute,)

  • Brian T. Edelson

    (Department of Pathology and Immunology,)

  • Peter R. Wilker

    (Department of Pathology and Immunology,)

  • Kai Hildner

    (Department of Pathology and Immunology,
    Howard Hughes Medical Institute,)

  • Carlo Mejia

    (Department of Pathology and Immunology,
    Howard Hughes Medical Institute,)

  • William A. Frazier

    (Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA)

  • Theresa L. Murphy

    (Department of Pathology and Immunology,)

  • Kenneth M. Murphy

    (Department of Pathology and Immunology,
    Howard Hughes Medical Institute,)

Abstract

Red pulp macrophage formation Red pulp macrophages are a distinct subset of tissue macrophages found in the spleen, and are thought to be involved in removal of senescent red blood cells. Kohyama et al. this week show that Spi-C, a PU.1-related transcription factor, selectively controls the development of red pulp macrophages. Spi-C-deficient mice fail to phagocytose trapped red blood cells. This is the first report of a transcription factor controlling the development of a tissue macrophage subset, and provides an example of a disorder in iron homeostasis caused by the loss of a specific cell lineage.

Suggested Citation

  • Masako Kohyama & Wataru Ise & Brian T. Edelson & Peter R. Wilker & Kai Hildner & Carlo Mejia & William A. Frazier & Theresa L. Murphy & Kenneth M. Murphy, 2009. "Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis," Nature, Nature, vol. 457(7227), pages 318-321, January.
    • Handle: RePEc:nat:nature:v:457:y:2009:i:7227:d:10.1038_nature07472
    DOI: 10.1038/nature07472
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    Cited by:

    1. Joschka Hey & Michelle Paulsen & Reka Toth & Dieter Weichenhan & Simone Butz & Jolanthe Schatterny & Reinhard Liebers & Pavlo Lutsik & Christoph Plass & Marcus A. Mall, 2021. "Epigenetic reprogramming of airway macrophages promotes polarization and inflammation in muco-obstructive lung disease," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    2. Graham A. Heieis & Thiago A. Patente & Luís Almeida & Frank Vrieling & Tamar Tak & Georgia Perona-Wright & Rick M. Maizels & Rinke Stienstra & Bart Everts, 2023. "Metabolic heterogeneity of tissue-resident macrophages in homeostasis and during helminth infection," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Surapon Tangvarasittichai, 2018. "Iron Homeostasis and Diabetes Risk," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 7(4), pages 1-11, July.
    4. Farshad Babaeijandaghi & Nasim Kajabadi & Reece Long & Lin Wei Tung & Chun Wai Cheung & Morten Ritso & Chih-Kai Chang & Ryan Cheng & Tiffany Huang & Elena Groppa & Jean X. Jiang & Fabio M. V. Rossi, 2023. "DPPIV+ fibro-adipogenic progenitors form the niche of adult skeletal muscle self-renewing resident macrophages," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    5. Surapon Tangvarasittichai, 2018. "Iron Homeostasis and Diabetes Risk," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 7(4), pages 79-88, July.

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