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Regulation of species metabolism in synthetic community systems by environmental pH oscillations

Author

Listed:
  • Shubin Li

    (Harbin Institute of Technology)

  • Yingming Zhao

    (Harbin Institute of Technology)

  • Shuqi Wu

    (Zhejiang University)

  • Xiangxiang Zhang

    (Harbin Institute of Technology)

  • Boyu Yang

    (Harbin Institute of Technology)

  • Liangfei Tian

    (Zhejiang University)

  • Xiaojun Han

    (Harbin Institute of Technology)

Abstract

Constructing a synthetic community system helps scientist understand the complex interactions among species in a community and its environment. Herein, a two-species community is constructed with species A (artificial cells encapsulating pH-responsive molecules and sucrose) and species B (Saccharomyces cerevisiae), which causes the environment to exhibit pH oscillation behaviour due to the generation and dissipation of CO2. In addition, a three-species community is constructed with species A′ (artificial cells containing sucrose and G6P), species B, and species C (artificial cells containing NAD+ and G6PDH). The solution pH oscillation regulates the periodical release of G6P from species A′; G6P then enters species C to promote the metabolic reaction that converts NAD+ to NADH. The location of species A′ and B determines the metabolism behaviour in species C in the spatially coded three-species communities with CA′B, CBA′, and A′CB patterns. The proposed synthetic community system provides a foundation to construct a more complicated microecosystem.

Suggested Citation

  • Shubin Li & Yingming Zhao & Shuqi Wu & Xiangxiang Zhang & Boyu Yang & Liangfei Tian & Xiaojun Han, 2023. "Regulation of species metabolism in synthetic community systems by environmental pH oscillations," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43398-6
    DOI: 10.1038/s41467-023-43398-6
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    References listed on IDEAS

    as
    1. Shunshi Kohyama & Adrián Merino-Salomón & Petra Schwille, 2022. "In vitro assembly, positioning and contraction of a division ring in minimal cells," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Qingchuan Li & Shubin Li & Xiangxiang Zhang & Weili Xu & Xiaojun Han, 2020. "Programmed magnetic manipulation of vesicles into spatially coded prototissue architectures arrays," Nature Communications, Nature, vol. 11(1), pages 1-9, December.
    3. Can Xu & Nicolas Martin & Mei Li & Stephen Mann, 2022. "Living material assembly of bacteriogenic protocells," Nature, Nature, vol. 609(7929), pages 1029-1037, September.
    4. Xiangxiang Zhang & Chao Li & Fukai Liu & Wei Mu & Yongshuo Ren & Boyu Yang & Xiaojun Han, 2022. "High-throughput production of functional prototissues capable of producing NO for vasodilation," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
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