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Mechanically induced pyroptosis enhances cardiosphere oxidative stress resistance and metabolism for myocardial infarction therapy

Author

Listed:
  • Yingwei Wang

    (Jinan University)

  • Qi Li

    (Jinan University)

  • Jupeng Zhao

    (Jinan University)

  • Jiamin Chen

    (Jinan University)

  • Dongxue Wu

    (First Affiliated Hospital of Jinan University)

  • Youling Zheng

    (Jinan University)

  • Jiaxin Wu

    (Jinan University)

  • Jie Liu

    (Jinan University)

  • Jianlong Lu

    (Jinan University)

  • Jianhua Zhang

    (First Affiliated Hospital of Jinan University)

  • Zheng Wu

    (Jinan University)

Abstract

Current approaches in myocardial infarction treatment are limited by low cellular oxidative stress resistance, reducing the long-term survival of therapeutic cells. Here we develop a liquid-crystal substrate with unique surface properties and mechanical responsiveness to produce size-controllable cardiospheres that undergo pyroptosis to improve cellular bioactivities and resistance to oxidative stress. We perform RNA sequencing and study cell metabolism to reveal increased metabolic levels and improved mitochondrial function in the preconditioned cardiospheres. We test therapeutic outcomes in a rat model of myocardial infarction to show that cardiospheres improve long-term cardiac function, promote angiogenesis and reduce cardiac remodeling during the 3-month observation. Overall, this study presents a promising and effective system for preparing a large quantity of functional cardiospheres, showcasing potential for clinical application.

Suggested Citation

  • Yingwei Wang & Qi Li & Jupeng Zhao & Jiamin Chen & Dongxue Wu & Youling Zheng & Jiaxin Wu & Jie Liu & Jianlong Lu & Jianhua Zhang & Zheng Wu, 2023. "Mechanically induced pyroptosis enhances cardiosphere oxidative stress resistance and metabolism for myocardial infarction therapy," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41700-0
    DOI: 10.1038/s41467-023-41700-0
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    References listed on IDEAS

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    1. Kyogo Kawaguchi & Ryoichiro Kageyama & Masaki Sano, 2017. "Topological defects control collective dynamics in neural progenitor cell cultures," Nature, Nature, vol. 545(7654), pages 327-331, May.
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    3. Thuan Beng Saw & Amin Doostmohammadi & Vincent Nier & Leyla Kocgozlu & Sumesh Thampi & Yusuke Toyama & Philippe Marcq & Chwee Teck Lim & Julia M. Yeomans & Benoit Ladoux, 2017. "Topological defects in epithelia govern cell death and extrusion," Nature, Nature, vol. 544(7649), pages 212-216, April.
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