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Timing of antibiotic administration determines the spread of plasmid-encoded antibiotic resistance during microbial range expansion

Author

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  • Yinyin Ma

    (Swiss Federal Institute of Aquatic Science and Technology (Eawag)
    Swiss Federal Institute of Technology (ETH))

  • Josep Ramoneda

    (Swiss Federal Institute of Aquatic Science and Technology (Eawag)
    University of Colorado)

  • David R. Johnson

    (Swiss Federal Institute of Aquatic Science and Technology (Eawag)
    University of Bern)

Abstract

Plasmids are the main vector by which antibiotic resistance is transferred between bacterial cells within surface-associated communities. In this study, we ask whether there is an optimal time to administer antibiotics to minimize plasmid spread in new bacterial genotypes during community expansion across surfaces. We address this question using consortia of Pseudomonas stutzeri strains, where one is an antibiotic resistance-encoding plasmid donor and the other a potential recipient. We allowed the strains to co-expand across a surface and administered antibiotics at different times. We find that plasmid transfer and transconjugant proliferation have unimodal relationships with the timing of antibiotic administration, where they reach maxima at intermediate times. These unimodal relationships result from the interplay between the probabilities of plasmid transfer and loss. Our study provides mechanistic insights into the transfer and proliferation of antibiotic resistance-encoding plasmids within microbial communities and identifies the timing of antibiotic administration as an important determinant.

Suggested Citation

  • Yinyin Ma & Josep Ramoneda & David R. Johnson, 2023. "Timing of antibiotic administration determines the spread of plasmid-encoded antibiotic resistance during microbial range expansion," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-39354-z
    DOI: 10.1038/s41467-023-39354-z
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    References listed on IDEAS

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    1. Erik Bakkeren & Jana S. Huisman & Stefan A. Fattinger & Annika Hausmann & Markus Furter & Adrian Egli & Emma Slack & Mikael E. Sellin & Sebastian Bonhoeffer & Roland R. Regoes & Médéric Diard & Wolf-D, 2019. "Salmonella persisters promote the spread of antibiotic resistance plasmids in the gut," Nature, Nature, vol. 573(7773), pages 276-280, September.
    2. Allison J. Lopatkin & Hannah R. Meredith & Jaydeep K. Srimani & Connor Pfeiffer & Rick Durrett & Lingchong You, 2017. "Persistence and reversal of plasmid-mediated antibiotic resistance," Nature Communications, Nature, vol. 8(1), pages 1-10, December.
    3. Helmut Hirt & Kerryl E. Greenwood-Quaintance & Aaron M. T. Barnes & Melissa J. Karau & Lisa M. Till & Elise Palzer & Weihua Guan & Michael S. VanNieuwenhze & Purna C. Kashyap & Robin Patel & Gary M. D, 2022. "Dynamics of plasmid-mediated niche invasion, immunity to invasion, and pheromone-inducible conjugation in the murine gastrointestinal tract," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    4. Tanita Wein & Nils F. Hülter & Itzhak Mizrahi & Tal Dagan, 2019. "Emergence of plasmid stability under non-selective conditions maintains antibiotic resistance," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
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    Cited by:

    1. Chujin Ruan & Josep Ramoneda & Anton Kan & Timothy J. Rudge & Gang Wang & David R. Johnson, 2024. "Phage predation accelerates the spread of plasmid-encoded antibiotic resistance," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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