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The contributions of mitochondrial and nuclear mitochondrial genetic variation to neuroticism

Author

Listed:
  • Charley Xia

    (University of Edinburgh
    University of Edinburgh)

  • Sarah J. Pickett

    (Newcastle University)

  • David C. M. Liewald

    (University of Edinburgh
    University of Edinburgh)

  • Alexander Weiss

    (University of Edinburgh)

  • Gavin Hudson

    (Newcastle University)

  • W. David Hill

    (University of Edinburgh
    University of Edinburgh)

Abstract

Neuroticism is a heritable trait composed of separate facets, each conferring different levels of protection or risk, to health. By examining mitochondrial DNA in 269,506 individuals, we show mitochondrial haplogroups explain 0.07-0.01% of variance in neuroticism and identify five haplogroup and 15 mitochondria-marker associations across a general factor of neuroticism, and two special factors of anxiety/tension, and worry/vulnerability with effect sizes of the same magnitude as autosomal variants. Within-haplogroup genome-wide association studies identified H-haplogroup-specific autosomal effects explaining 1.4% variance of worry/vulnerability. These H-haplogroup-specific autosomal effects show a pleiotropic relationship with cognitive, physical and mental health that differs from that found when assessing autosomal effects across haplogroups. We identify interactions between chromosome 9 regions and mitochondrial haplogroups at P

Suggested Citation

  • Charley Xia & Sarah J. Pickett & David C. M. Liewald & Alexander Weiss & Gavin Hudson & W. David Hill, 2023. "The contributions of mitochondrial and nuclear mitochondrial genetic variation to neuroticism," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38480-y
    DOI: 10.1038/s41467-023-38480-y
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