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Genomic mutation landscape of skin cancers from DNA repair-deficient xeroderma pigmentosum patients

Author

Listed:
  • Andrey A. Yurchenko

    (Université Paris Saclay)

  • Fatemeh Rajabi

    (Université Paris Saclay)

  • Tirzah Braz-Petta

    (Universidade Federal do Rio Grande do Norte, Av. Senador Salgado Filho, s/n)

  • Hiva Fassihi

    (St John’s Institute of Dermatology, Guy’s and St Thomas’ Foundation Trust)

  • Alan Lehmann

    (St John’s Institute of Dermatology, Guy’s and St Thomas’ Foundation Trust
    University of Sussex, Falmer)

  • Chikako Nishigori

    (Kobe University Graduate School of Medicine)

  • Jinxin Wang

    (Université Paris Saclay)

  • Ismael Padioleau

    (Université Paris Saclay)

  • Konstantin Gunbin

    (Université Paris Saclay)

  • Leonardo Panunzi

    (Université Paris Saclay)

  • Fanny Morice-Picard

    (Service de Dermatologie, CHU de Bordeaux)

  • Pierre Laplante

    (Université Paris Saclay)

  • Caroline Robert

    (Université Paris Saclay
    Gustave Roussy and Paris-Saclay University)

  • Patricia L. Kannouche

    (Université Paris-Saclay)

  • Carlos F. M. Menck

    (University of Sao Paulo)

  • Alain Sarasin

    (Université Paris-Saclay)

  • Sergey I. Nikolaev

    (Université Paris Saclay)

Abstract

Xeroderma pigmentosum (XP) is a genetic disorder caused by mutations in genes of the Nucleotide Excision Repair (NER) pathway (groups A-G) or in Translesion Synthesis DNA polymerase η (V). XP is associated with an increased skin cancer risk, reaching, for some groups, several thousand-fold compared to the general population. Here, we analyze 38 skin cancer genomes from five XP groups. We find that the activity of NER determines heterogeneity of the mutation rates across skin cancer genomes and that transcription-coupled NER extends beyond the gene boundaries reducing the intergenic mutation rate. Mutational profile in XP-V tumors and experiments with POLH knockout cell line reveal the role of polymerase η in the error-free bypass of (i) rare TpG and TpA DNA lesions, (ii) 3’ nucleotides in pyrimidine dimers, and (iii) TpT photodimers. Our study unravels the genetic basis of skin cancer risk in XP and provides insights into the mechanisms reducing UV-induced mutagenesis in the general population.

Suggested Citation

  • Andrey A. Yurchenko & Fatemeh Rajabi & Tirzah Braz-Petta & Hiva Fassihi & Alan Lehmann & Chikako Nishigori & Jinxin Wang & Ismael Padioleau & Konstantin Gunbin & Leonardo Panunzi & Fanny Morice-Picard, 2023. "Genomic mutation landscape of skin cancers from DNA repair-deficient xeroderma pigmentosum patients," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38311-0
    DOI: 10.1038/s41467-023-38311-0
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