IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v488y2012i7412d10.1038_nature11273.html
   My bibliography  Save this article

Chromatin organization is a major influence on regional mutation rates in human cancer cells

Author

Listed:
  • Benjamin Schuster-Böckler

    (EMBL-CRG Systems Biology Unit, CRG and UPF, Barcelona 08003, Spain
    Pear Computer LLP, London W5 1SH, UK)

  • Ben Lehner

    (EMBL-CRG Systems Biology Unit, CRG and UPF, Barcelona 08003, Spain
    Institució Catalana de Recerca i Estudis Avançats (ICREA), Passeig Lluís Companys, 23, Barcelona 08010, Spain)

Abstract

Mutation rates in cancer genomes are closely related to chromatin organization, indicating that the arrangement of the genome into heterochromatin- and euchromatin-like domains may be a dominant influence on variation in regional mutation rate in human somatic cells.

Suggested Citation

  • Benjamin Schuster-Böckler & Ben Lehner, 2012. "Chromatin organization is a major influence on regional mutation rates in human cancer cells," Nature, Nature, vol. 488(7412), pages 504-507, August.
    • Handle: RePEc:nat:nature:v:488:y:2012:i:7412:d:10.1038_nature11273
    DOI: 10.1038/nature11273
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature11273
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature11273?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Luan Nguyen & Arne Hoeck & Edwin Cuppen, 2022. "Machine learning-based tissue of origin classification for cancer of unknown primary diagnostics using genome-wide mutation features," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. Michael Habig & Cecile Lorrain & Alice Feurtey & Jovan Komluski & Eva H. Stukenbrock, 2021. "Epigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    3. Andrey A. Yurchenko & Fatemeh Rajabi & Tirzah Braz-Petta & Hiva Fassihi & Alan Lehmann & Chikako Nishigori & Jinxin Wang & Ismael Padioleau & Konstantin Gunbin & Leonardo Panunzi & Fanny Morice-Picard, 2023. "Genomic mutation landscape of skin cancers from DNA repair-deficient xeroderma pigmentosum patients," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    4. Mischan Vali-Pour & Solip Park & Jose Espinosa-Carrasco & Daniel Ortiz-Martínez & Ben Lehner & Fran Supek, 2022. "The impact of rare germline variants on human somatic mutation processes," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    5. Clara Lopes Novo & Emily V. Wong & Colin Hockings & Chetan Poudel & Eleanor Sheekey & Meike Wiese & Hanneke Okkenhaug & Simon J. Boulton & Srinjan Basu & Simon Walker & Gabriele S. Kaminski Schierle &, 2022. "Satellite repeat transcripts modulate heterochromatin condensates and safeguard chromosome stability in mouse embryonic stem cells," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:488:y:2012:i:7412:d:10.1038_nature11273. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.