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A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates

Author

Listed:
  • Payton A.-B. Weidenbacher

    (Stanford University
    Stanford University)

  • Mrinmoy Sanyal

    (Stanford University
    Stanford University)

  • Natalia Friedland

    (Stanford University
    Stanford University)

  • Shaogeng Tang

    (Stanford University
    Stanford University)

  • Prabhu S. Arunachalam

    (Stanford University School of Medicine)

  • Mengyun Hu

    (Stanford University School of Medicine)

  • Ozan S. Kumru

    (University of Kansas)

  • Mary Kate Morris

    (California Department of Public Health)

  • Jane Fontenot

    (University of Louisiana at Lafayette)

  • Lisa Shirreff

    (University of Louisiana at Lafayette)

  • Jonathan Do

    (Stanford University
    Stanford University)

  • Ya-Chen Cheng

    (Stanford University
    Stanford University)

  • Gayathri Vasudevan

    (IAVI)

  • Mark B. Feinberg

    (IAVI)

  • Francois J. Villinger

    (University of Louisiana at Lafayette)

  • Carl Hanson

    (California Department of Public Health)

  • Sangeeta B. Joshi

    (University of Kansas)

  • David B. Volkin

    (University of Kansas)

  • Bali Pulendran

    (Stanford University School of Medicine
    Stanford University School of Medicine
    Stanford University School of Medicine)

  • Peter S. Kim

    (Stanford University
    Stanford University
    Chan Zuckerberg Biohub)

Abstract

While the rapid development of COVID-19 vaccines has been a scientific triumph, the need remains for a globally available vaccine that provides longer-lasting immunity against present and future SARS-CoV-2 variants of concern (VOCs). Here, we describe DCFHP, a ferritin-based, protein-nanoparticle vaccine candidate that, when formulated with aluminum hydroxide as the sole adjuvant (DCFHP-alum), elicits potent and durable neutralizing antisera in non-human primates against known VOCs, including Omicron BQ.1, as well as against SARS-CoV-1. Following a booster ~one year after the initial immunization, DCFHP-alum elicits a robust anamnestic response. To enable global accessibility, we generated a cell line that can enable production of thousands of vaccine doses per liter of cell culture and show that DCFHP-alum maintains potency for at least 14 days at temperatures exceeding standard room temperature. DCFHP-alum has potential as a once-yearly (or less frequent) booster vaccine, and as a primary vaccine for pediatric use including in infants.

Suggested Citation

  • Payton A.-B. Weidenbacher & Mrinmoy Sanyal & Natalia Friedland & Shaogeng Tang & Prabhu S. Arunachalam & Mengyun Hu & Ozan S. Kumru & Mary Kate Morris & Jane Fontenot & Lisa Shirreff & Jonathan Do & Y, 2023. "A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37417-9
    DOI: 10.1038/s41467-023-37417-9
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    1. Sandile Cele & Laurelle Jackson & David S. Khoury & Khadija Khan & Thandeka Moyo-Gwete & Houriiyah Tegally & James Emmanuel San & Deborah Cromer & Cathrine Scheepers & Daniel G. Amoako & Farina Karim , 2022. "Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization," Nature, Nature, vol. 602(7898), pages 654-656, February.
    2. Katherine McMahan & Jingyou Yu & Noe B. Mercado & Carolin Loos & Lisa H. Tostanoski & Abishek Chandrashekar & Jinyan Liu & Lauren Peter & Caroline Atyeo & Alex Zhu & Esther A. Bondzie & Gabriel Dagott, 2021. "Correlates of protection against SARS-CoV-2 in rhesus macaques," Nature, Nature, vol. 590(7847), pages 630-634, February.
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