IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-47743-1.html
   My bibliography  Save this article

An ancestral SARS-CoV-2 vaccine induces anti-Omicron variants antibodies by hypermutation

Author

Listed:
  • Seoryeong Park

    (Seoul National University College of Medicine
    Seoul National University College of Medicine)

  • Jaewon Choi

    (Seoul National University
    Seoul National University)

  • Yonghee Lee

    (Seoul National University)

  • Jinsung Noh

    (Seoul National University
    Seoul National University)

  • Namphil Kim

    (Seoul National University)

  • JinAh Lee

    (Institut Pasteur Korea)

  • Geummi Cho

    (Seoul National University College of Medicine
    Seoul National University College of Medicine)

  • Sujeong Kim

    (Seoul National University College of Medicine
    Seoul National University College of Medicine)

  • Duck Kyun Yoo

    (Seoul National University College of Medicine
    Seoul National University College of Medicine)

  • Chang Kyung Kang

    (Seoul National University College of Medicine)

  • Pyoeng Gyun Choe

    (Seoul National University College of Medicine)

  • Nam Joong Kim

    (Seoul National University College of Medicine)

  • Wan Beom Park

    (Seoul National University College of Medicine)

  • Seungtaek Kim

    (Institut Pasteur Korea)

  • Myoung-don Oh

    (Seoul National University College of Medicine)

  • Sunghoon Kwon

    (Seoul National University
    Seoul National University
    Seoul National University)

  • Junho Chung

    (Seoul National University College of Medicine
    Seoul National University College of Medicine
    Seoul National University College of Medicine)

Abstract

The immune escape of Omicron variants significantly subsides by the third dose of an mRNA vaccine. However, it is unclear how Omicron variant-neutralizing antibodies develop under repeated vaccination. We analyze blood samples from 41 BNT162b2 vaccinees following the course of three injections and analyze their B-cell receptor (BCR) repertoires at six time points in total. The concomitant reactivity to both ancestral and Omicron receptor-binding domain (RBD) is achieved by a limited number of BCR clonotypes depending on the accumulation of somatic hypermutation (SHM) after the third dose. Our findings suggest that SHM accumulation in the BCR space to broaden its specificity for unseen antigens is a counterprotective mechanism against virus variant immune escape.

Suggested Citation

  • Seoryeong Park & Jaewon Choi & Yonghee Lee & Jinsung Noh & Namphil Kim & JinAh Lee & Geummi Cho & Sujeong Kim & Duck Kyun Yoo & Chang Kyung Kang & Pyoeng Gyun Choe & Nam Joong Kim & Wan Beom Park & Se, 2024. "An ancestral SARS-CoV-2 vaccine induces anti-Omicron variants antibodies by hypermutation," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47743-1
    DOI: 10.1038/s41467-024-47743-1
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-47743-1
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-47743-1?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47743-1. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.