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Genetic correlates of vitamin D-binding protein and 25-hydroxyvitamin D in neonatal dried blood spots

Author

Listed:
  • Clara Albiñana

    (Aarhus University)

  • Zhihong Zhu

    (Aarhus University)

  • Nis Borbye-Lorenzen

    (Statens Serum Institut)

  • Sanne Grundvad Boelt

    (Statens Serum Institut
    Statens Serum Institut)

  • Arieh S. Cohen

    (Testcenter Denmark, Statens Serum Institut)

  • Kristin Skogstrand

    (Statens Serum Institut)

  • Naomi R. Wray

    (University of Queensland
    University of Queensland)

  • Joana A. Revez

    (University of Queensland)

  • Florian Privé

    (Aarhus University)

  • Liselotte V. Petersen

    (Aarhus University
    The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH)

  • Cynthia M. Bulik

    (University of North Carolina at Chapel Hill
    Karolinska Institutet
    University of North Carolina at Chapel Hill)

  • Oleguer Plana-Ripoll

    (Aarhus University
    Aarhus University and Aarhus University Hospital)

  • Katherine L. Musliner

    (Aarhus University and Aarhus University Hospital-Psychiatry)

  • Esben Agerbo

    (Aarhus University
    The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH
    Aarhus University)

  • Anders D. Børglum

    (The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH
    Aarhus University
    Aarhus University)

  • David M. Hougaard

    (The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH
    Statens Serum Institut)

  • Merete Nordentoft

    (The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH
    University of Copenhagen
    University of Copenhagen)

  • Thomas Werge

    (The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH
    Copenhagen University Hospital
    University of Copenhagen
    University of Copenhagen)

  • Preben Bo Mortensen

    (Aarhus University
    The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH
    Aarhus University)

  • Bjarni J. Vilhjálmsson

    (Aarhus University
    The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH
    Aarhus University)

  • John J. McGrath

    (Aarhus University
    University of Queensland
    The Park Centre for Mental Health)

Abstract

The vitamin D binding protein (DBP), encoded by the group-specific component (GC) gene, is a component of the vitamin D system. In a genome-wide association study of DBP concentration in 65,589 neonates we identify 26 independent loci, 17 of which are in or close to the GC gene, with fine-mapping identifying 2 missense variants on chromosomes 12 and 17 (within SH2B3 and GSDMA, respectively). When adjusted for GC haplotypes, we find 15 independent loci distributed over 10 chromosomes. Mendelian randomization analyses identify a unidirectional effect of higher DBP concentration and (a) higher 25-hydroxyvitamin D concentration, and (b) a reduced risk of multiple sclerosis and rheumatoid arthritis. A phenome-wide association study confirms that higher DBP concentration is associated with a reduced risk of vitamin D deficiency. Our findings provide valuable insights into the influence of DBP on vitamin D status and a range of health outcomes.

Suggested Citation

  • Clara Albiñana & Zhihong Zhu & Nis Borbye-Lorenzen & Sanne Grundvad Boelt & Arieh S. Cohen & Kristin Skogstrand & Naomi R. Wray & Joana A. Revez & Florian Privé & Liselotte V. Petersen & Cynthia M. Bu, 2023. "Genetic correlates of vitamin D-binding protein and 25-hydroxyvitamin D in neonatal dried blood spots," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-36392-5
    DOI: 10.1038/s41467-023-36392-5
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    References listed on IDEAS

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