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Long-term memory CD8+ T cells specific for SARS-CoV-2 in individuals who received the BNT162b2 mRNA vaccine

Author

Listed:
  • Nozomi Kuse

    (Kumamoto University)

  • Yu Zhang

    (Kumamoto University)

  • Takayuki Chikata

    (Kumamoto University)

  • Hung The Nguyen

    (Kumamoto University)

  • Shinichi Oka

    (Kumamoto University
    National Center for Global Health and Medicine)

  • Hiroyuki Gatanaga

    (Kumamoto University
    National Center for Global Health and Medicine)

  • Masafumi Takiguchi

    (Kumamoto University)

Abstract

Long-term memory T cells have not been well analyzed in individuals vaccinated with a COVID-19 vaccine although analysis of these T cells is necessary to evaluate vaccine efficacy. Here, investigate HLA-A*24:02-restricted CD8+ T cells specific for SARS-CoV-2-derived spike (S) epitopes in individuals immunized with the BNT162b2 mRNA vaccine. T cells specific for the S-QI9 and S-NF9 immunodominant epitopes have higher ability to recognize epitopes than other epitope-specific T cell populations. This higher recognition of S-QI9-specific T cells is due to the high stability of the S-QI9 peptide for HLA-A*24:02, whereas that of S-NF9-specific T cells results from the high affinity of T cell receptor. T cells specific for S-QI9 and S-NF9 are detectable >30 weeks after the second vaccination, indicating that the vaccine induces long-term memory T cells specific for these epitopes. Because the S-QI9 epitope is highly conserved among SARS-CoV-2 variants, S-QI9-specific T cells may help prevent infection with SARS-CoV-2 variants.

Suggested Citation

  • Nozomi Kuse & Yu Zhang & Takayuki Chikata & Hung The Nguyen & Shinichi Oka & Hiroyuki Gatanaga & Masafumi Takiguchi, 2022. "Long-term memory CD8+ T cells specific for SARS-CoV-2 in individuals who received the BNT162b2 mRNA vaccine," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32989-4
    DOI: 10.1038/s41467-022-32989-4
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    1. Ugur Sahin & Alexander Muik & Evelyna Derhovanessian & Isabel Vogler & Lena M. Kranz & Mathias Vormehr & Alina Baum & Kristen Pascal & Jasmin Quandt & Daniel Maurus & Sebastian Brachtendorf & Verena L, 2020. "COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses," Nature, Nature, vol. 586(7830), pages 594-599, October.
    2. Petra Mlcochova & Steven A. Kemp & Mahesh Shanker Dhar & Guido Papa & Bo Meng & Isabella A. T. M. Ferreira & Rawlings Datir & Dami A. Collier & Anna Albecka & Sujeet Singh & Rajesh Pandey & Jonathan B, 2021. "SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion," Nature, Nature, vol. 599(7883), pages 114-119, November.
    3. Ugur Sahin & Alexander Muik & Isabel Vogler & Evelyna Derhovanessian & Lena M. Kranz & Mathias Vormehr & Jasmin Quandt & Nicole Bidmon & Alexander Ulges & Alina Baum & Kristen E. Pascal & Daniel Mauru, 2021. "BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells in humans," Nature, Nature, vol. 595(7868), pages 572-577, July.
    4. Jinyan Liu & Abishek Chandrashekar & Daniel Sellers & Julia Barrett & Catherine Jacob-Dolan & Michelle Lifton & Katherine McMahan & Michaela Sciacca & Haley VanWyk & Cindy Wu & Jingyou Yu & Ai-ris Y. , 2022. "Vaccines elicit highly conserved cellular immunity to SARS-CoV-2 Omicron," Nature, Nature, vol. 603(7901), pages 493-496, March.
    5. Delphine Planas & David Veyer & Artem Baidaliuk & Isabelle Staropoli & Florence Guivel-Benhassine & Maaran Michael Rajah & Cyril Planchais & Françoise Porrot & Nicolas Robillard & Julien Puech & Matth, 2021. "Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization," Nature, Nature, vol. 596(7871), pages 276-280, August.
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