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Neutralizing activity of BBIBP-CorV vaccine-elicited sera against Beta, Delta and other SARS-CoV-2 variants of concern

Author

Listed:
  • Xiaoqi Yu

    (Shanghai Jiao Tong University School of Medicine)

  • Dong Wei

    (Shanghai Jiao Tong University School of Medicine)

  • Wenxin Xu

    (Shanghai Jiao Tong University School of Medicine)

  • Chuanmiao Liu

    (First Affiliated Hospital of Bengbu Medical College)

  • Wentian Guo

    (Shanghai Jiao Tong University School of Medicine)

  • Xinxin Li

    (Shanghai Jiao Tong University School of Medicine)

  • Wei Tan

    (Shanghai Jiao Tong University School of Medicine)

  • Leshan Liu

    (Shanghai Jiao Tong University School of Medicine)

  • Xinxin Zhang

    (Shanghai Jiao Tong University School of Medicine
    Shanghai Jiao Tong University School of Medicine)

  • Jieming Qu

    (Shanghai Jiao Tong University School of Medicine
    Shanghai Jiao Tong University School of Medicine
    Shanghai Key Laboratory of Emergency Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases)

  • Zhitao Yang

    (Shanghai Jiao Tong University School of Medicine)

  • Erzhen Chen

    (Shanghai Jiao Tong University School of Medicine)

Abstract

The global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in the generation of variants that may diminish host immune responses to vaccine formulations. Here we show a registered observational clinical trial (NCT04795414), we assess the safety and immunogenicity of the inactivated SARS-CoV-2 vaccine BBIBP-CorV in a cohort of 1006 vaccine recipients. No serious adverse events are observed during the term of the study. Detectable virus-specific antibody is measured and determined to be neutralizing in 698/760 (91.84%) vaccine recipients on day 28 post second vaccine dose and in 220/581 (37.87%) vaccine recipients on day 180 post second vaccine dose, whereas vaccine-elicited sera show varying degrees of reduction in neutralization against a range of key SARS-CoV-2 variants, including variant Alpha, Beta, Gamma, Iota, and Delta. Our work show diminished neutralization potency against multiple variants in vaccine-elicited sera, which indicates the potential need for additional boost vaccinations.

Suggested Citation

  • Xiaoqi Yu & Dong Wei & Wenxin Xu & Chuanmiao Liu & Wentian Guo & Xinxin Li & Wei Tan & Leshan Liu & Xinxin Zhang & Jieming Qu & Zhitao Yang & Erzhen Chen, 2022. "Neutralizing activity of BBIBP-CorV vaccine-elicited sera against Beta, Delta and other SARS-CoV-2 variants of concern," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29477-0
    DOI: 10.1038/s41467-022-29477-0
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    Cited by:

    1. Nawal Al Kaabi & Yun Kai Yang & Li Fang Du & Ke Xu & Shuai Shao & Yu Liang & Yun Kang & Ji Guo Su & Jing Zhang & Tian Yang & Salah Hussein & Mohamed Saif ElDein & Sen Sen Yang & Wenwen Lei & Xue Jun G, 2022. "Safety and immunogenicity of a hybrid-type vaccine booster in BBIBP-CorV recipients in a randomized phase 2 trial," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

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