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cAMP and c-di-GMP synergistically support biofilm maintenance through the direct interaction of their effectors

Author

Listed:
  • Cong Liu

    (Jiangsu Normal University)

  • Di Sun

    (Jiangsu Normal University)

  • Jiawen Liu

    (Jiangsu Normal University)

  • Ying Chen

    (Jiangsu Normal University)

  • Xuge Zhou

    (Jiangsu Normal University)

  • Yunrui Ru

    (Jiangsu Normal University)

  • Jingrong Zhu

    (Jiangsu Normal University)

  • Weijie Liu

    (Jiangsu Normal University)

Abstract

Nucleotide second messengers, such as cAMP and c-di-GMP, regulate many physiological processes in bacteria, including biofilm formation. There is evidence of cross-talk between pathways mediated by c-di-GMP and those mediated by the cAMP receptor protein (CRP), but the mechanisms are often unclear. Here, we show that cAMP-CRP modulates biofilm maintenance in Shewanella putrefaciens not only via its known effects on gene transcription, but also through direct interaction with a putative c-di-GMP effector on the inner membrane, BpfD. Binding of cAMP-CRP to BpfD enhances the known interaction of BpfD with protease BpfG, which prevents proteolytic processing and release of a cell surface-associated adhesin, BpfA, thus contributing to biofilm maintenance. Our results provide evidence of cross-talk between cAMP and c-di-GMP pathways through direct interaction of their effectors, and indicate that cAMP-CRP can play regulatory roles at the post-translational level.

Suggested Citation

  • Cong Liu & Di Sun & Jiawen Liu & Ying Chen & Xuge Zhou & Yunrui Ru & Jingrong Zhu & Weijie Liu, 2022. "cAMP and c-di-GMP synergistically support biofilm maintenance through the direct interaction of their effectors," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29240-5
    DOI: 10.1038/s41467-022-29240-5
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    1. Kyle A. Floyd & Calvin K. Lee & Wujing Xian & Mahmoud Nametalla & Aneesa Valentine & Benjamin Crair & Shiwei Zhu & Hannah Q. Hughes & Jennifer L. Chlebek & Daniel C. Wu & Jin Hwan Park & Ali M. Farhat, 2020. "c-di-GMP modulates type IV MSHA pilus retraction and surface attachment in Vibrio cholerae," Nature Communications, Nature, vol. 11(1), pages 1-16, December.
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    1. Xiaocui Ling & Xiao Liu & Kun Wang & Minhao Guo & Yanzhe Ou & Danting Li & Yulin Xiang & Jiachen Zheng & Lihua Hu & Hongyun Zhang & Weihui Li, 2024. "Lsr2 acts as a cyclic di-GMP receptor that promotes keto-mycolic acid synthesis and biofilm formation in mycobacteria," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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