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Efficient protein incorporation and release by a jigsaw-shaped self-assembling peptide hydrogel for injured brain regeneration

Author

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  • Atsuya Yaguchi

    (Tokyo University of Agriculture and Technology)

  • Mio Oshikawa

    (Center for Brain Integration Research (CBIR), Tokyo Medical and Dental University (TMDU)
    Kanagawa Institute of Industrial Science and Technology (KISTEC))

  • Go Watanabe

    (Kanagawa Institute of Industrial Science and Technology (KISTEC)
    Kitasato University)

  • Hirotsugu Hiramatsu

    (National Yang Ming Chiao Tung University
    Center for Emergent Functional Matter Science, National Yang Ming Chiao Tung University)

  • Noriyuki Uchida

    (Tokyo University of Agriculture and Technology)

  • Chikako Hara

    (Center for Brain Integration Research (CBIR), Tokyo Medical and Dental University (TMDU)
    Kanagawa Institute of Industrial Science and Technology (KISTEC))

  • Naoko Kaneko

    (Nagoya City University Graduate School of Medical Sciences)

  • Kazunobu Sawamoto

    (Nagoya City University Graduate School of Medical Sciences
    National Institute for Physiological Sciences)

  • Takahiro Muraoka

    (Tokyo University of Agriculture and Technology
    Kanagawa Institute of Industrial Science and Technology (KISTEC))

  • Itsuki Ajioka

    (Center for Brain Integration Research (CBIR), Tokyo Medical and Dental University (TMDU)
    Kanagawa Institute of Industrial Science and Technology (KISTEC))

Abstract

During injured tissue regeneration, the extracellular matrix plays a key role in controlling and coordinating various cellular events by binding and releasing secreted proteins in addition to promoting cell adhesion. Herein, we develop a cell-adhesive fiber-forming peptide that mimics the jigsaw-shaped hydrophobic surface in the dovetail-packing motif of glycophorin A as an artificial extracellular matrix for regenerative therapy. We show that the jigsaw-shaped self-assembling peptide forms several-micrometer-long supramolecular nanofibers through a helix-to-strand transition to afford a hydrogel under physiological conditions and disperses homogeneously in the hydrogel. The molecular- and macro-scale supramolecular properties of the jigsaw-shaped self-assembling peptide hydrogel allow efficient incorporation and sustained release of vascular endothelial growth factor, and demonstrate cell transplantation-free regenerative therapeutic effects in a subacute-chronic phase mouse stroke model. This research highlights a therapeutic strategy for injured tissue regeneration using the jigsaw-shaped self-assembling peptide supramolecular hydrogel.

Suggested Citation

  • Atsuya Yaguchi & Mio Oshikawa & Go Watanabe & Hirotsugu Hiramatsu & Noriyuki Uchida & Chikako Hara & Naoko Kaneko & Kazunobu Sawamoto & Takahiro Muraoka & Itsuki Ajioka, 2021. "Efficient protein incorporation and release by a jigsaw-shaped self-assembling peptide hydrogel for injured brain regeneration," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26896-3
    DOI: 10.1038/s41467-021-26896-3
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    References listed on IDEAS

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    1. Peter Carmeliet, 2005. "Angiogenesis in life, disease and medicine," Nature, Nature, vol. 438(7070), pages 932-936, December.
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