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Biological Characterization of Cynara cardunculus L. Methanolic Extracts: Antioxidant, Anti-proliferative, Anti-migratory and Anti-angiogenic Activities

Author

Listed:
  • Zélia Velez

    () (Center for Marine Sciences (CCMAR), Universidade do Algarve Campus de Gambelas, 8005-139 Faro, Portugal
    Centro de Biotecnologia Agrícola e Agro-Alimentar do Baixo Alentejo e Litoral (CEBAL), Instituto Politécnico de Beja (IPBeja), 7801-908 Beja, Portugal)

  • Marco A. Campinho

    () (Center for Marine Sciences (CCMAR), Universidade do Algarve Campus de Gambelas, 8005-139 Faro, Portugal)

  • Ângela R. Guerra

    (Centro de Biotecnologia Agrícola e Agro-Alimentar do Baixo Alentejo e Litoral (CEBAL), Instituto Politécnico de Beja (IPBeja), 7801-908 Beja, Portugal
    Centre for Research in Ceramics & Composite Materials (CICECO), University of Aveiro, 3810-193 Aveiro, Portugal)

  • Laura García

    () (Centro de Biotecnologia Agrícola e Agro-Alimentar do Baixo Alentejo e Litoral (CEBAL), Instituto Politécnico de Beja (IPBeja), 7801-908 Beja, Portugal)

  • Patricia Ramos

    () (Centro de Biotecnologia Agrícola e Agro-Alimentar do Baixo Alentejo e Litoral (CEBAL), Instituto Politécnico de Beja (IPBeja), 7801-908 Beja, Portugal
    Centre for Research in Ceramics & Composite Materials (CICECO), University of Aveiro, 3810-193 Aveiro, Portugal)

  • Olinda Guerreiro

    () (Centro de Biotecnologia Agrícola e Agro-Alimentar do Baixo Alentejo e Litoral (CEBAL), Instituto Politécnico de Beja (IPBeja), 7801-908 Beja, Portugal
    Centre for Research in Ceramics & Composite Materials (CICECO), University of Aveiro, 3810-193 Aveiro, Portugal)

  • Laura Felício

    () (Centro de Biotecnologia Agrícola e Agro-Alimentar do Baixo Alentejo e Litoral (CEBAL), Instituto Politécnico de Beja (IPBeja), 7801-908 Beja, Portugal)

  • Fernando Schmitt

    () (Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), University of Porto, 4200-465 Porto, Portugal
    Department of Pathology and Oncology, Medical Faculty of University of Porto, 4200-319 Porto, Portugal)

  • Maria Duarte

    () (Centro de Biotecnologia Agrícola e Agro-Alimentar do Baixo Alentejo e Litoral (CEBAL), Instituto Politécnico de Beja (IPBeja), 7801-908 Beja, Portugal
    Centre for Research in Ceramics & Composite Materials (CICECO), University of Aveiro, 3810-193 Aveiro, Portugal)

Abstract

Cynara cardunculus (Cc) is a multipurpose species; beyond its use in southwestern European cuisine, it is also used for the production of solid biofuel, seed oil, biodiesel, paper pulp and cheese, as well as animal feed. In addition, Cc has a long tradition of use in folk medicine as a diuretic and liver protector. The value of this species as a source of bioactive compounds is known; however, pharmacological use would further increase its cultivation. The main goal of the current work was to evaluate the potential of Cc as source of anti-carcinogenic phytochemicals. Different methanolic extracts obtained from wild and cultivated plants were tested for antioxidant activity and effect on breast tumor cell viability. The most effective extract, both as antioxidant and inhibition of tumor cell viability, was tested for effects on angiogenesis and tumor cell migration capacity. All the extracts tested had high antioxidant activity; however, only green leaves and dry head extracts exhibit anti-proliferative activity. Green cultivated leaves (GCL) were the most effective extract both as antioxidant and inhibiting the proliferation of tumor cells; it is equally active inhibiting tumor cell migration and in vivo angiogenesis. GCL extract is an effective inhibitor of several key points in tumor development and thus a promising source of anti-carcinogenic phytochemicals.

Suggested Citation

  • Zélia Velez & Marco A. Campinho & Ângela R. Guerra & Laura García & Patricia Ramos & Olinda Guerreiro & Laura Felício & Fernando Schmitt & Maria Duarte, 2012. "Biological Characterization of Cynara cardunculus L. Methanolic Extracts: Antioxidant, Anti-proliferative, Anti-migratory and Anti-angiogenic Activities," Agriculture, MDPI, Open Access Journal, vol. 2(4), pages 1-21, December.
  • Handle: RePEc:gam:jagris:v:2:y:2012:i:4:p:472-492:d:22314
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    More about this item

    Keywords

    Cynara cardunculus ; phenols; antioxidant; antitumor; breast cancer;

    JEL classification:

    • Q1 - Agricultural and Natural Resource Economics; Environmental and Ecological Economics - - Agriculture
    • Q10 - Agricultural and Natural Resource Economics; Environmental and Ecological Economics - - Agriculture - - - General
    • Q11 - Agricultural and Natural Resource Economics; Environmental and Ecological Economics - - Agriculture - - - Aggregate Supply and Demand Analysis; Prices
    • Q12 - Agricultural and Natural Resource Economics; Environmental and Ecological Economics - - Agriculture - - - Micro Analysis of Farm Firms, Farm Households, and Farm Input Markets
    • Q13 - Agricultural and Natural Resource Economics; Environmental and Ecological Economics - - Agriculture - - - Agricultural Markets and Marketing; Cooperatives; Agribusiness
    • Q14 - Agricultural and Natural Resource Economics; Environmental and Ecological Economics - - Agriculture - - - Agricultural Finance
    • Q15 - Agricultural and Natural Resource Economics; Environmental and Ecological Economics - - Agriculture - - - Land Ownership and Tenure; Land Reform; Land Use; Irrigation; Agriculture and Environment
    • Q16 - Agricultural and Natural Resource Economics; Environmental and Ecological Economics - - Agriculture - - - R&D; Agricultural Technology; Biofuels; Agricultural Extension Services
    • Q17 - Agricultural and Natural Resource Economics; Environmental and Ecological Economics - - Agriculture - - - Agriculture in International Trade
    • Q18 - Agricultural and Natural Resource Economics; Environmental and Ecological Economics - - Agriculture - - - Agricultural Policy; Food Policy

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