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Arabidopsis P4 ATPase-mediated cell detoxification confers resistance to Fusarium graminearum and Verticillium dahliae

Author

Listed:
  • Fanlong Wang

    (Southwest University)

  • Xianbi Li

    (Southwest University)

  • Yujie Li

    (Southwest University)

  • Jing Han

    (Southwest University)

  • Yang Chen

    (Southwest University)

  • Jianyan Zeng

    (Southwest University)

  • Mei Su

    (Southwest University)

  • Jingxin Zhuo

    (Southwest University)

  • Hui Ren

    (Southwest University)

  • Haoru Liu

    (Southwest University)

  • Lei Hou

    (Southwest University)

  • Yanhua Fan

    (Southwest University)

  • Xingying Yan

    (Southwest University)

  • Shuiqing Song

    (Southwest University)

  • Juan Zhao

    (Southwest University)

  • Dan Jin

    (Southwest University)

  • Mi Zhang

    (Southwest University)

  • Yan Pei

    (Southwest University)

Abstract

Many toxic secondary metabolites produced by phytopathogens can subvert host immunity, and some of them are recognized as pathogenicity factors. Fusarium head blight and Verticillium wilt are destructive plant diseases worldwide. Using toxins produced by the causal fungi Fusarium graminearum and Verticillium dahliae as screening agents, here we show that the Arabidopsis P4 ATPases AtALA1 and AtALA7 are responsible for cellular detoxification of mycotoxins. Through AtALA1-/AtALA7-mediated vesicle transport, toxins are sequestered in vacuoles for degradation. Overexpression of AtALA1 and AtALA7 significantly increases the resistance of transgenic plants to F. graminearum and V. dahliae, respectively. Notably, the concentration of deoxynivalenol, a mycotoxin harmful to the health of humans and animals, was decreased in transgenic Arabidopsis siliques and maize seeds. This vesicle-mediated cell detoxification process provides a strategy to increase plant resistance against different toxin-associated diseases and to reduce the mycotoxin contamination in food and feed.

Suggested Citation

  • Fanlong Wang & Xianbi Li & Yujie Li & Jing Han & Yang Chen & Jianyan Zeng & Mei Su & Jingxin Zhuo & Hui Ren & Haoru Liu & Lei Hou & Yanhua Fan & Xingying Yan & Shuiqing Song & Juan Zhao & Dan Jin & Mi, 2021. "Arabidopsis P4 ATPase-mediated cell detoxification confers resistance to Fusarium graminearum and Verticillium dahliae," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26727-5
    DOI: 10.1038/s41467-021-26727-5
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    References listed on IDEAS

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    1. Harvey T. McMahon & Jennifer L. Gallop, 2005. "Membrane curvature and mechanisms of dynamic cell membrane remodelling," Nature, Nature, vol. 438(7068), pages 590-596, December.
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