IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v12y2021i1d10.1038_s41467-021-26126-w.html
   My bibliography  Save this article

A bioinspired scaffold for rapid oxygenation of cell encapsulation systems

Author

Listed:
  • Long-Hai Wang

    (Biological and Environmental Engineering, Cornell University)

  • Alexander Ulrich Ernst

    (Biological and Environmental Engineering, Cornell University)

  • Duo An

    (Biological and Environmental Engineering, Cornell University)

  • Ashim Kumar Datta

    (Biological and Environmental Engineering, Cornell University)

  • Boris Epel

    (The University of Chicago)

  • Mrignayani Kotecha

    (O2M Technologies, LLC)

  • Minglin Ma

    (Biological and Environmental Engineering, Cornell University)

Abstract

Inadequate oxygenation is a major challenge in cell encapsulation, a therapy which holds potential to treat many diseases including type I diabetes. In such systems, cellular oxygen (O2) delivery is limited to slow passive diffusion from transplantation sites through the poorly O2-soluble encapsulating matrix, usually a hydrogel. This constrains the maximum permitted distance between the encapsulated cells and host site to within a few hundred micrometers to ensure cellular function. Inspired by the natural gas-phase tracheal O2 delivery system of insects, we present herein the design of a biomimetic scaffold featuring internal continuous air channels endowed with 10,000-fold higher O2 diffusivity than hydrogels. We incorporate the scaffold into a bulk hydrogel containing cells, which facilitates rapid O2 transport through the whole system to cells several millimeters away from the device-host boundary. A computational model, validated by in vitro analysis, predicts that cells and islets maintain high viability even in a thick (6.6 mm) device. Finally, the therapeutic potential of the device is demonstrated through the correction of diabetes in immunocompetent mice using rat islets for over 6 months.

Suggested Citation

  • Long-Hai Wang & Alexander Ulrich Ernst & Duo An & Ashim Kumar Datta & Boris Epel & Mrignayani Kotecha & Minglin Ma, 2021. "A bioinspired scaffold for rapid oxygenation of cell encapsulation systems," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26126-w
    DOI: 10.1038/s41467-021-26126-w
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-26126-w
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-021-26126-w?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Iain D. Couzin & Jens Krause & Nigel R. Franks & Simon A. Levin, 2005. "Effective leadership and decision-making in animal groups on the move," Nature, Nature, vol. 433(7025), pages 513-516, February.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Hamoon Hemmatpour & Oreste Luca & Dominic Crestani & Marc C. A. Stuart & Alessia Lasorsa & Patrick C. A. Wel & Katja Loos & Theodosis Giousis & Vahid Haddadi-Asl & Petra Rudolf, 2023. "New insights in polydopamine formation via surface adsorption," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Jesus Paez-Mayorga & Jocelyn Nikita Campa-Carranza & Simone Capuani & Nathanael Hernandez & Hsuan-Chen Liu & Corrine Ying Xuan Chua & Fernanda Paola Pons-Faudoa & Gulsah Malgir & Bella Alvarez & Jean , 2022. "Implantable niche with local immunosuppression for islet allotransplantation achieves type 1 diabetes reversal in rats," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    3. Alexander U. Ernst & Long-Hai Wang & Scott C. Worland & Braulio A. Marfil-Garza & Xi Wang & Wanjun Liu & Alan Chiu & Tatsuya Kin & Doug O’Gorman & Scott Steinschneider & Ashim K. Datta & Klearchos K. , 2022. "A predictive computational platform for optimizing the design of bioartificial pancreas devices," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Simon Levin & Anastasios Xepapadeas, 2021. "On the Coevolution of Economic and Ecological Systems," Annual Review of Resource Economics, Annual Reviews, vol. 13(1), pages 355-377, October.
    2. Becco, Ch. & Vandewalle, N. & Delcourt, J. & Poncin, P., 2006. "Experimental evidences of a structural and dynamical transition in fish school," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 367(C), pages 487-493.
    3. Richard P Mann, 2011. "Bayesian Inference for Identifying Interaction Rules in Moving Animal Groups," PLOS ONE, Public Library of Science, vol. 6(8), pages 1-10, August.
    4. Ma, Jian & Song, Wei-guo & Zhang, Jun & Lo, Siu-ming & Liao, Guang-xuan, 2010. "k-Nearest-Neighbor interaction induced self-organized pedestrian counter flow," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 389(10), pages 2101-2117.
    5. Andrew Hoegh & Frank T. Manen & Mark Haroldson, 2021. "Agent-Based Models for Collective Animal Movement: Proximity-Induced State Switching," Journal of Agricultural, Biological and Environmental Statistics, Springer;The International Biometric Society;American Statistical Association, vol. 26(4), pages 560-579, December.
    6. Tamás Nepusz & Tamás Vicsek, 2013. "Hierarchical Self-Organization of Non-Cooperating Individuals," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-9, December.
    7. Amos Korman & Efrat Greenwald & Ofer Feinerman, 2014. "Confidence Sharing: An Economic Strategy for Efficient Information Flows in Animal Groups," PLOS Computational Biology, Public Library of Science, vol. 10(10), pages 1-10, October.
    8. Roy Harpaz & Minh Nguyet Nguyen & Armin Bahl & Florian Engert, 2021. "Precise visuomotor transformations underlying collective behavior in larval zebrafish," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    9. Li, Qing & Zhang, Lingwei & Jia, Yongnan & Lu, Tianzhao & Chen, Xiaojie, 2022. "Modeling, analysis, and optimization of three-dimensional restricted visual field metric-free swarms," Chaos, Solitons & Fractals, Elsevier, vol. 157(C).
    10. Mathew Titus & George Hagstrom & James R Watson, 2021. "Unsupervised manifold learning of collective behavior," PLOS Computational Biology, Public Library of Science, vol. 17(2), pages 1-20, February.
    11. Sophie Lardy & Daniel Fortin & Olivier Pays, 2016. "Increased Exploration Capacity Promotes Group Fission in Gregarious Foraging Herbivores," PLOS ONE, Public Library of Science, vol. 11(12), pages 1-14, December.
    12. Fan, Kangqi & Pedrycz, Witold, 2016. "Opinion evolution influenced by informed agents," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 462(C), pages 431-441.
    13. De Rosis, Alessandro, 2014. "Hydrodynamic effects on a predator approaching a group of preys," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 414(C), pages 329-339.
    14. Shao, Zhi-Gang & Yang, Yan-Yan, 2015. "Effective strategies of collective evacuation from an enclosed space," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 427(C), pages 34-39.
    15. Panpan Yang & Maode Yan & Jiacheng Song & Ye Tang, 2019. "Self-Organized Fission-Fusion Control Algorithm for Flocking Systems Based on Intermittent Selective Interaction," Complexity, Hindawi, vol. 2019, pages 1-12, February.
    16. Huepe, Cristián & Aldana, Maximino, 2008. "New tools for characterizing swarming systems: A comparison of minimal models," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 387(12), pages 2809-2822.
    17. Federico Pratissoli & Andreagiovanni Reina & Yuri Kaszubowski Lopes & Carlo Pinciroli & Genki Miyauchi & Lorenzo Sabattini & Roderich Groß, 2023. "Coherent movement of error-prone individuals through mechanical coupling," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    18. Milad Haghani & Majid Sarvi & Zahra Shahhoseini & Maik Boltes, 2016. "How Simple Hypothetical-Choice Experiments Can Be Utilized to Learn Humans’ Navigational Escape Decisions in Emergencies," PLOS ONE, Public Library of Science, vol. 11(11), pages 1-24, November.
    19. Kim, Jong-Ho & Park, Jea-Hyun, 2022. "Clustering phenomenon of the singular Cucker–Smale model with finite communication weight and variable coupling strength," Chaos, Solitons & Fractals, Elsevier, vol. 164(C).
    20. Mayuko Nakamaru & Akira Yokoyama, 2014. "The Effect of Ostracism and Optional Participation on the Evolution of Cooperation in the Voluntary Public Goods Game," PLOS ONE, Public Library of Science, vol. 9(9), pages 1-9, September.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26126-w. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.