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Skeletal muscle transcriptome in healthy aging

Author

Listed:
  • Robert A. Tumasian

    (National Institute on Aging–Intramural Research Program, National Institutes of Health)

  • Abhinav Harish

    (National Institute on Aging–Intramural Research Program, National Institutes of Health)

  • Gautam Kundu

    (National Institute on Aging–Intramural Research Program, National Institutes of Health)

  • Jen-Hao Yang

    (National Institute on Aging–Intramural Research Program, National Institutes of Health)

  • Ceereena Ubaida-Mohien

    (National Institute on Aging–Intramural Research Program, National Institutes of Health)

  • Marta Gonzalez-Freire

    (National Institute on Aging–Intramural Research Program, National Institutes of Health)

  • Mary Kaileh

    (National Institute on Aging–Intramural Research Program, National Institutes of Health)

  • Linda M. Zukley

    (National Institute on Aging–Intramural Research Program, National Institutes of Health)

  • Chee W. Chia

    (National Institute on Aging–Intramural Research Program, National Institutes of Health)

  • Alexey Lyashkov

    (National Institute on Aging–Intramural Research Program, National Institutes of Health)

  • William H. Wood

    (National Institute on Aging–Intramural Research Program, National Institutes of Health)

  • Yulan Piao

    (National Institute on Aging–Intramural Research Program, National Institutes of Health)

  • Christopher Coletta

    (National Institute on Aging–Intramural Research Program, National Institutes of Health)

  • Jun Ding

    (National Institute on Aging–Intramural Research Program, National Institutes of Health)

  • Myriam Gorospe

    (National Institute on Aging–Intramural Research Program, National Institutes of Health)

  • Ranjan Sen

    (National Institute on Aging–Intramural Research Program, National Institutes of Health)

  • Supriyo De

    (National Institute on Aging–Intramural Research Program, National Institutes of Health)

  • Luigi Ferrucci

    (National Institute on Aging–Intramural Research Program, National Institutes of Health)

Abstract

Age-associated changes in gene expression in skeletal muscle of healthy individuals reflect accumulation of damage and compensatory adaptations to preserve tissue integrity. To characterize these changes, RNA was extracted and sequenced from muscle biopsies collected from 53 healthy individuals (22–83 years old) of the GESTALT study of the National Institute on Aging–NIH. Expression levels of 57,205 protein-coding and non-coding RNAs were studied as a function of aging by linear and negative binomial regression models. From both models, 1134 RNAs changed significantly with age. The most differentially abundant mRNAs encoded proteins implicated in several age-related processes, including cellular senescence, insulin signaling, and myogenesis. Specific mRNA isoforms that changed significantly with age in skeletal muscle were enriched for proteins involved in oxidative phosphorylation and adipogenesis. Our study establishes a detailed framework of the global transcriptome and mRNA isoforms that govern muscle damage and homeostasis with age.

Suggested Citation

  • Robert A. Tumasian & Abhinav Harish & Gautam Kundu & Jen-Hao Yang & Ceereena Ubaida-Mohien & Marta Gonzalez-Freire & Mary Kaileh & Linda M. Zukley & Chee W. Chia & Alexey Lyashkov & William H. Wood & , 2021. "Skeletal muscle transcriptome in healthy aging," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22168-2
    DOI: 10.1038/s41467-021-22168-2
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    Cited by:

    1. Vaid, Shashank & Donthu, Naveen, 2023. "When injured product users may also stay satisfied: A macro-level analysis," Journal of Business Research, Elsevier, vol. 162(C).

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