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Evaluating a Prediction-Driven Targeting Strategy for Reducing the Transmission of Multidrug-Resistant Organisms

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  • Sean L. Barnes

    (Department of Decision, Operations and Information Technologies, Robert H. Smith School of Business, University of Maryland, College Park, Maryland 20742;)

  • Miranda Myers

    (Department of Decision, Operations and Information Technologies, Robert H. Smith School of Business, University of Maryland, College Park, Maryland 20742;)

  • Clare Rock

    (Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205;)

  • Daniel J. Morgan

    (Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland 21201)

  • Lisa Pineles

    (Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland 21201)

  • Kerri A. Thom

    (Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland 21201)

  • Anthony D. Harris

    (Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland 21201)

Abstract

The transmission of multidrug-resistant organisms (MDROs) in the healthcare setting is an ongoing challenge affecting at least 2 million patients in the United States each year via infection and leading to over 20,000 deaths. Many mathematical models have been developed to approximate MDRO transmission dynamics, focusing most often on evaluating the impact of various infection-control strategies. However, although the insights derived from these studies are useful, the models do not typically have the ability to support decision making for infection-control practitioners in real time. In this study, we design a detailed agent-based model of MDRO transmission—focusing on methicillin-resistant Staphylococcus aureus in the intensive care unit setting—and validate its transmission dynamics using data collected during a multisite randomized, controlled trial. We leverage this model to develop and evaluate the effectiveness of a prediction-driven approach for targeting patients for contact precautions (i.e., requiring all visiting healthcare workers to wear personal protective equipment) in a simulated intensive care unit based on their daily likelihood of becoming colonized by the organism. We show that we can predict these outcomes with moderate to high accuracy across a broad range of scenarios and that these predictions can be used to efficiently target patients for intervention and, ultimately, to reduce the overall acquisition rate in the unit.

Suggested Citation

  • Sean L. Barnes & Miranda Myers & Clare Rock & Daniel J. Morgan & Lisa Pineles & Kerri A. Thom & Anthony D. Harris, 2020. "Evaluating a Prediction-Driven Targeting Strategy for Reducing the Transmission of Multidrug-Resistant Organisms," INFORMS Journal on Computing, INFORMS, vol. 32(4), pages 912-929, October.
    • Handle: RePEc:inm:orijoc:v:32:y:4:i:2020:p:912-929
    DOI: 10.1287/ijoc.2019.0916
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    References listed on IDEAS

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    1. Sean Barnes & Bruce Golden & Edward Wasil, 2010. "MRSA Transmission Reduction Using Agent-Based Modeling and Simulation," INFORMS Journal on Computing, INFORMS, vol. 22(4), pages 635-646, November.
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