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Nonalcoholic Steatohepatitis Animal Model, Induced by High-Fat Diet and Tetracycline

Author

Listed:
  • David Areshidze
  • Lyudmila Timchenko
  • Ivan Syomin
  • Maria Kozlova
  • Igor. Rzhepakovsky

Abstract

As a result of research it was succeeded to receive the model of non-alcoholic steatohepatitis which is characterized by obesity, violation of the structural organization, a fabric necrosis, formation of fibrosis of a liver. The developed model of non-alcoholic steatohepatitis allows to study also staging of development of a fatty desease of the liver which is characterized by formation of a steatogepatitis and fibrosis. In quality the inducing factors the high-fat diet and antibiotics were used. The offered NASH model can be used in the field of chronic experiments for an assessment of extent of violation of a functional condition of hepatobiliary system and for search of the effective pharmacotheurapeutichepatoprotective agents.

Suggested Citation

  • David Areshidze & Lyudmila Timchenko & Ivan Syomin & Maria Kozlova & Igor. Rzhepakovsky, 2015. "Nonalcoholic Steatohepatitis Animal Model, Induced by High-Fat Diet and Tetracycline," Modern Applied Science, Canadian Center of Science and Education, vol. 9(1), pages 170-170, January.
    • Handle: RePEc:ibn:masjnl:v:9:y:2015:i:1:p:170
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    JEL classification:

    • R00 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - General - - - General
    • Z0 - Other Special Topics - - General

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