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Design, Synthesis and Antifungal Activity of 3-substituedmethylenethiochroman-4-one Derivatives

Author

Listed:
  • Xinghua Zhang
  • Zhengyue Ma
  • Gengliang Yang
  • Yajun Zheng

Abstract

Four new 3-substituedmethylenethiochroman-4-one derivatives were prepared from (z)-3-(chlorome- thylene)thiochroman-4-one. They were characterized by analytical and spectral methods. In vitro antifungal activities of these synthesized compounds were evaluated against ten species of fungi, and the results showed that (e)-3-chloromethylene compound exhibited a similar good activity against fungi to (z)-3-chloromethylene compound. (Z)-3-substituedaminomethylene compound also exhibited antifungi activity to some extent.

Suggested Citation

  • Xinghua Zhang & Zhengyue Ma & Gengliang Yang & Yajun Zheng, 2011. "Design, Synthesis and Antifungal Activity of 3-substituedmethylenethiochroman-4-one Derivatives," Modern Applied Science, Canadian Center of Science and Education, vol. 5(1), pages 217-217, February.
    • Handle: RePEc:ibn:masjnl:v:5:y:2011:i:1:p:217
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    JEL classification:

    • R00 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - General - - - General
    • Z0 - Other Special Topics - - General

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