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Association of Tumor Growth Factor-β and Interferon-γ Serum Levels With Insulin Resistance in Normal Pregnancy

Author

Listed:
  • Abdolreza Sotoodeh Jahromi
  • Mohammad Sadegh Sanie
  • Alireza Yusefi
  • Hassan Zabetian
  • Parvin Zareian
  • Hossein Hakimelahi
  • Abdolhossien Madani
  • Mohammad Hojjat-Farsangi

Abstract

Pregnancy is related to change in glucose metabolism and insulin production. The aim of our study was to determine the association of serum IFN-γ and TGF- β levels with insulin resistance during normal pregnancy. This cross sectional study was carried out on 97 healthy pregnant (in different trimesters) and 28 healthy non-pregnant women. Serum TGF-β and IFN- γ level were measured by ELISA method. Pregnant women had high level TGF-β and low level IFN-γ as compared non-pregnant women. Maternal serum TGF-β concentration significantly increased in third trimester as compared first and second trimester of pregnancy. Maternal serum IFN-γ concentration significantly decreased in third trimester as compared first and second trimester of pregnancy. Pregnant women exhibited higher score of HOMA IR as compared non-pregnant women. There were association between gestational age with body mass index (r=0.28, P=0.005), TGF-β (r=0.45, P<0.001) and IFN-γ (r=-0.50, P<0.001). There was significant association between Insulin resistance and TGF-β (r=0.17, p=0.05). Our findings suggest that changes in maternal cytokine level in healthy pregnant women were anti-inflammatory. Furthermore, Tumor Growth Factor-β appears has a role in induction insulin resistance in healthy pregnant women. However, further studies needed to evaluate role of different cytokines on insulin resistance in normal pregnancy.

Suggested Citation

  • Abdolreza Sotoodeh Jahromi & Mohammad Sadegh Sanie & Alireza Yusefi & Hassan Zabetian & Parvin Zareian & Hossein Hakimelahi & Abdolhossien Madani & Mohammad Hojjat-Farsangi, 2016. "Association of Tumor Growth Factor-β and Interferon-γ Serum Levels With Insulin Resistance in Normal Pregnancy," Global Journal of Health Science, Canadian Center of Science and Education, vol. 8(6), pages 1-25, June.
    • Handle: RePEc:ibn:gjhsjl:v:8:y:2016:i:6:p:25
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    JEL classification:

    • R00 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - General - - - General
    • Z0 - Other Special Topics - - General

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