IDEAS home Printed from https://ideas.repec.org/a/ibn/gjhsjl/v8y2016i10p185.html
   My bibliography  Save this article

Azithromycin versus Cephalexin for Simple Traumatic Wounds in the Emergency Department: A Randomised Trial

Author

Listed:
  • Hamed Ghafouri
  • Morteza Zare
  • Azam Bazrafshan
  • Abbas Edalatkhah
  • Niloofar Abazarian

Abstract

OBJECTIVE- The aim of this study was to investigate efficacy of azithromycin versus cephalexin for infection prophylaxisis in patients with simple traumatic wounds managed at emergency department.METHOD- This randomized controlled trial compared short-course therapy of once-daily azithromycin (500 mg before the wound repair followed by 250 mg/day for 5 days) with cephalexin (1000 mg before wound repair followed by 250 mg every 6 hours for 5 days) in the treatment of patients with simple traumatic wounds. A total of 366 patients were randomly selected for the study and 303 were evaluated for the final analysis.RESULTS- On completion of therapy, the rate of observed infection was 9.6% in the cephalexin group (15 patients, odds ratio=0.77, 95% confidence interval, 0.56 to 1.06) and 5.4% in the azithromycin group (8 patients, odds ratio 1.42, 95% confidence interval, 0.80 to 2.52). Both treatment indicated similar prophylactic efficacy during the study (P=0.197).CONCLUSION- Our study showed that Azithromycin as infection prophylaxis in simple traumatic wounds had the same effect as cephalexin but azithromycin is easier to use and more cost-effective compared to cephalexin.

Suggested Citation

  • Hamed Ghafouri & Morteza Zare & Azam Bazrafshan & Abbas Edalatkhah & Niloofar Abazarian, 2016. "Azithromycin versus Cephalexin for Simple Traumatic Wounds in the Emergency Department: A Randomised Trial," Global Journal of Health Science, Canadian Center of Science and Education, vol. 8(10), pages 185-185, October.
    • Handle: RePEc:ibn:gjhsjl:v:8:y:2016:i:10:p:185
    as

    Download full text from publisher

    File URL: http://www.ccsenet.org/journal/index.php/gjhs/article/download/54891/30807
    Download Restriction: no
    File URL: http://www.ccsenet.org/journal/index.php/gjhs/article/view/54891
    Download Restriction: no
    ---><---

    More about this item

    JEL classification:

    • R00 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - General - - - General
    • Z0 - Other Special Topics - - General

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:ibn:gjhsjl:v:8:y:2016:i:10:p:185. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Canadian Center of Science and Education (email available below). General contact details of provider: https://edirc.repec.org/data/cepflch.html .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.