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Serum Aspartic Acid ‎as a Marker of Epilepsy

Author

Listed:
  • Gheyath AlGawwam
  • Asaad Adil Mnaather
  • Akram Al-Mahdawi
  • Hayder A. Fawzi
  • Laith G. ‎ Shareef

Abstract

OBJECTIVE- Determine the ‎diagnostic validity of serum aspartic acid as a predictor of epilepsy. STUDY DESIGN & METHODOLOGY- This study enrolled 80 epileptic patients and 80 healthy people, and we measure serum level of ‎aspartic acid by using high liquid performance chromatography. RESULTS- Mean serum aspartic acid ‎was significantly higher in patients (26.2 ± 10.1) mg\dl while in control was (2.8 ± 1.36) mg\dl, ‎the result showed that aspartic acid is an excellent predictor area under the curve [AUC] (95%CI) = ‎‎0.988 (0.97 – 1.0) with 96.3% sensitivity and 97.5% specificity for epileptic patients. Also, the ‎result shows generalized seizure has significantly higher mean serum aspartic acid compared to ‎partial type and GTC show significantly higher mean serum aspartic acid compared to ‎myoclonus. CONCLUSION- Aspartic acid serum level markedly elevated in epileptic patients ‎groups in comparison to the healthy group, also shows a marked difference between generalized ‎and partial epilepsy and show different levels between subtypes of epilepsy.‎

Suggested Citation

  • Gheyath AlGawwam & Asaad Adil Mnaather & Akram Al-Mahdawi & Hayder A. Fawzi & Laith G. ‎ Shareef, 2019. "Serum Aspartic Acid ‎as a Marker of Epilepsy," Global Journal of Health Science, Canadian Center of Science and Education, vol. 11(2), pages 142-142, February.
    • Handle: RePEc:ibn:gjhsjl:v:11:y:2019:i:2:p:142
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    • R00 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - General - - - General
    • Z0 - Other Special Topics - - General

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