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A Fractional-Order Model for HIV Dynamics in a Two-Sex Population

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  • Fatmawati
  • Endrik Mifta Shaiful
  • Mohammad Imam Utoyo

Abstract

Human Immunodeficiency Virus (HIV) is a virus that attacks or infects cells in the immune system that causes immune decline. Acquired Immunodeficiency Syndrome (AIDS) is the most severe stage of HIV infection. AIDS is the rapidly spreading and becoming epidemic diseases in the world of almost complete influence across the country. A mathematical model approach of HIV/AIDS dynamic is needed to predict the spread of the diseases in the future. In this paper, we presented a fractional-order model of the spread of HIV and AIDS diseases which incorporates two-sex population. The fractional derivative order of the model is in the interval . We compute the basic reproduction number and prove the stability of the equilibriums of the model. The sensitivity analysis also is done to determine the important factor controlling the spread. Using the Adams-type predictor-corrector method, we then perform some numerical simulations for variation values of the order of the fractional derivative. Finally, the effects of various antiretroviral therapy (ART) treatments are studied and compared with numerical approach.

Suggested Citation

  • Fatmawati & Endrik Mifta Shaiful & Mohammad Imam Utoyo, 2018. "A Fractional-Order Model for HIV Dynamics in a Two-Sex Population," International Journal of Mathematics and Mathematical Sciences, Hindawi, vol. 2018, pages 1-11, April.
    • Handle: RePEc:hin:jijmms:6801475
    DOI: 10.1155/2018/6801475
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    References listed on IDEAS

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    1. Yang, Wei & Shu, Zhan & Lam, James & Sun, Chengjun, 2017. "Global dynamics of an HIV model incorporating senior male clients," Applied Mathematics and Computation, Elsevier, vol. 311(C), pages 203-216.
    2. Fatmawati & Hengki Tasman, 2016. "An Optimal Treatment Control of TB-HIV Coinfection," International Journal of Mathematics and Mathematical Sciences, Hindawi, vol. 2016, pages 1-11, March.
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    Cited by:

    1. Naik, Parvaiz Ahmad & Zu, Jian & Owolabi, Kolade M., 2020. "Modeling the mechanics of viral kinetics under immune control during primary infection of HIV-1 with treatment in fractional order," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 545(C).
    2. Mohammad Imam Utoyo & Windarto & Aminatus Sa’adah, 2018. "Analysis of Fractional Order Mathematical Model of Hematopoietic Stem Cell Gene-Based Therapy," International Journal of Mathematics and Mathematical Sciences, Hindawi, vol. 2018, pages 1-11, August.
    3. Li, Zhongfei & Liu, Zhuang & Khan, Muhammad Altaf, 2020. "Fractional investigation of bank data with fractal-fractional Caputo derivative," Chaos, Solitons & Fractals, Elsevier, vol. 131(C).
    4. Naik, Parvaiz Ahmad & Zu, Jian & Owolabi, Kolade M., 2020. "Global dynamics of a fractional order model for the transmission of HIV epidemic with optimal control," Chaos, Solitons & Fractals, Elsevier, vol. 138(C).
    5. Wang, Wanting & Khan, Muhammad Altaf & Fatmawati, & Kumam, P. & Thounthong, P., 2019. "A comparison study of bank data in fractional calculus," Chaos, Solitons & Fractals, Elsevier, vol. 126(C), pages 369-384.
    6. Fatmawati, & Khan, Muhammad Altaf & Odinsyah, Hafidz Putra, 2020. "Fractional model of HIV transmission with awareness effect," Chaos, Solitons & Fractals, Elsevier, vol. 138(C).
    7. Khajji, Bouchaib & Kouidere, Abdelfatah & Elhia, Mohamed & Balatif, Omar & Rachik, Mostafa, 2021. "Fractional optimal control problem for an age-structured model of COVID-19 transmission," Chaos, Solitons & Fractals, Elsevier, vol. 143(C).
    8. Fatmawati, & Khan, Muhammad Altaf & Azizah, Muftiyatul & Windarto, & Ullah, Saif, 2019. "A fractional model for the dynamics of competition between commercial and rural banks in Indonesia," Chaos, Solitons & Fractals, Elsevier, vol. 122(C), pages 32-46.

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