IDEAS home Printed from https://ideas.repec.org/a/gam/jmathe/v11y2023i19p4063-d1247188.html
   My bibliography  Save this article

Effects of NMDA Receptor Hypofunction on Inhibitory Control in a Two-Layer Neural Circuit Model

Author

Listed:
  • Weijie Ye

    (School of Statistics and Mathematics, Guangdong University of Finance and Economics, Guangzhou 510320, China)

  • Xiaoying Chen

    (School of Statistics and Mathematics, Guangdong University of Finance and Economics, Guangzhou 510320, China)

Abstract

Inhibitory control plays an important role in controlling behaviors, and its impairment is a characteristic feature of schizophrenia. Such inhibitory control has been examined through the the stop-signal task, wherein participants are asked to suppress a planned movement when a stop signal appears. In this research, we constructed a two-layer spiking neural circuit model to study how N-methyl-D-aspartate receptor (NMDAR) hypofunction, a potential pathological mechanism in schizophrenia, impacts the inhibitory control ability in the stop-signal task. To find the possible NMDAR hypofunction effects in schizophrenia, all NMDA-mediated synapses in the model were set to be NMDAR hypofunction at different levels. Our findings revealed that the performances of the stop-signal task were close to the experimental results in schizophrenia when NMDAR hypofunction was present in the neurons of two populations that controlled the “go” process and the “stop” process of the stop-signal task, implying that the execution and inhibition of behaviors were both impaired in schizophrenia. Under a certain degree of NMDAR hypofunction, the circuit model is able to replicate the stop-signal task performances observed in individuals with schizophrenia. In addition, we have observed a predictable outcome indicating that NMDAR hypofunction can lower the saccadic threshold in the stop-signal task. These results provide a mechanical explanation for the impairment of inhibitory control in schizophrenia.

Suggested Citation

  • Weijie Ye & Xiaoying Chen, 2023. "Effects of NMDA Receptor Hypofunction on Inhibitory Control in a Two-Layer Neural Circuit Model," Mathematics, MDPI, vol. 11(19), pages 1-12, September.
    • Handle: RePEc:gam:jmathe:v:11:y:2023:i:19:p:4063-:d:1247188
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/2227-7390/11/19/4063/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/2227-7390/11/19/4063/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Ofer Yizhar & Lief E. Fenno & Matthias Prigge & Franziska Schneider & Thomas J. Davidson & Daniel J. O’Shea & Vikaas S. Sohal & Inbal Goshen & Joel Finkelstein & Jeanne T. Paz & Katja Stehfest & Roman, 2011. "Neocortical excitation/inhibition balance in information processing and social dysfunction," Nature, Nature, vol. 477(7363), pages 171-178, September.
    2. Yousheng Shu & Andrea Hasenstaub & David A. McCormick, 2003. "Turning on and off recurrent balanced cortical activity," Nature, Nature, vol. 423(6937), pages 288-293, May.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Cheng-Te Wang & Chung-Ting Lee & Xiao-Jing Wang & Chung-Chuan Lo, 2013. "Top-Down Modulation on Perceptual Decision with Balanced Inhibition through Feedforward and Feedback Inhibitory Neurons," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-14, April.
    2. Ashok Litwin-Kumar & Anne-Marie M Oswald & Nathaniel N Urban & Brent Doiron, 2011. "Balanced Synaptic Input Shapes the Correlation between Neural Spike Trains," PLOS Computational Biology, Public Library of Science, vol. 7(12), pages 1-14, December.
    3. Matteo Farinella & Daniel T Ruedt & Padraig Gleeson & Frederic Lanore & R Angus Silver, 2014. "Glutamate-Bound NMDARs Arising from In Vivo-like Network Activity Extend Spatio-temporal Integration in a L5 Cortical Pyramidal Cell Model," PLOS Computational Biology, Public Library of Science, vol. 10(4), pages 1-21, April.
    4. Alexandre Castonguay & Sébastien Thomas & Frédéric Lesage & Christian Casanova, 2014. "Repetitive and Retinotopically Restricted Activation of the Dorsal Lateral Geniculate Nucleus with Optogenetics," PLOS ONE, Public Library of Science, vol. 9(4), pages 1-8, April.
    5. Giulia Faini & Dimitrii Tanese & Clément Molinier & Cécile Telliez & Massilia Hamdani & Francois Blot & Christophe Tourain & Vincent Sars & Filippo Bene & Benoît C. Forget & Emiliano Ronzitti & Valent, 2023. "Ultrafast light targeting for high-throughput precise control of neuronal networks," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    6. Brandon W. Hughes & Jessica L. Huebschman & Evgeny Tsvetkov & Benjamin M. Siemsen & Kirsten K. Snyder & Rose Marie Akiki & Daniel J. Wood & Rachel D. Penrod & Michael D. Scofield & Stefano Berto & Mak, 2024. "NPAS4 supports cocaine-conditioned cues in rodents by controlling the cell type-specific activation balance in the nucleus accumbens," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    7. Pan Xu & Yuanlei Yue & Juntao Su & Xiaoqian Sun & Hongfei Du & Zhichao Liu & Rahul Simha & Jianhui Zhou & Chen Zeng & Hui Lu, 2022. "Pattern decorrelation in the mouse medial prefrontal cortex enables social preference and requires MeCP2," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    8. Yu-Jun Wang & Gui-Ying Zan & Cenglin Xu & Xue-Ping Li & Xuelian Shu & Song-Yu Yao & Xiao-Shan Xu & Xiaoyun Qiu & Yexiang Chen & Kai Jin & Qi-Xin Zhou & Jia-Yu Ye & Yi Wang & Lin Xu & Zhong Chen & Jing, 2023. "The claustrum-prelimbic cortex circuit through dynorphin/κ-opioid receptor signaling underlies depression-like behaviors associated with social stress etiology," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    9. Eunhye Cho & Jii Kwon & Gyuwon Lee & Jiwoo Shin & Hyunsu Lee & Suk-Ho Lee & Chun Kee Chung & Jaeyoung Yoon & Won-Kyung Ho, 2024. "Net synaptic drive of fast-spiking interneurons is inverted towards inhibition in human FCD I epilepsy," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    10. Alon Poleg-Polsky & Jeffrey S Diamond, 2011. "Imperfect Space Clamp Permits Electrotonic Interactions between Inhibitory and Excitatory Synaptic Conductances, Distorting Voltage Clamp Recordings," PLOS ONE, Public Library of Science, vol. 6(4), pages 1-11, April.
    11. Qingtao Sun & Jianping Zhang & Anan Li & Mei Yao & Guangcai Liu & Siqi Chen & Yue Luo & Zhi Wang & Hui Gong & Xiangning Li & Qingming Luo, 2022. "Acetylcholine deficiency disrupts extratelencephalic projection neurons in the prefrontal cortex in a mouse model of Alzheimer’s disease," Nature Communications, Nature, vol. 13(1), pages 1-22, December.
    12. Luye Qin & Jamal B. Williams & Tao Tan & Tiaotiao Liu & Qing Cao & Kaijie Ma & Zhen Yan, 2021. "Deficiency of autism risk factor ASH1L in prefrontal cortex induces epigenetic aberrations and seizures," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    13. David Holcman & Misha Tsodyks, 2006. "The Emergence of Up and Down States in Cortical Networks," PLOS Computational Biology, Public Library of Science, vol. 2(3), pages 1-8, March.
    14. Ghanim Ullah & Steven J Schiff, 2010. "Assimilating Seizure Dynamics," PLOS Computational Biology, Public Library of Science, vol. 6(5), pages 1-12, May.
    15. Andreas Steimer & Kaspar Schindler, 2015. "Random Sampling with Interspike-Intervals of the Exponential Integrate and Fire Neuron: A Computational Interpretation of UP-States," PLOS ONE, Public Library of Science, vol. 10(7), pages 1-26, July.
    16. Martin Boerlin & Christian K Machens & Sophie Denève, 2013. "Predictive Coding of Dynamical Variables in Balanced Spiking Networks," PLOS Computational Biology, Public Library of Science, vol. 9(11), pages 1-16, November.
    17. Lloyd E. Russell & Mehmet Fişek & Zidan Yang & Lynn Pei Tan & Adam M. Packer & Henry W. P. Dalgleish & Selmaan N. Chettih & Christopher D. Harvey & Michael Häusser, 2024. "The influence of cortical activity on perception depends on behavioral state and sensory context," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    18. Jorge Hidalgo & Luís F Seoane & Jesús M Cortés & Miguel A Muñoz, 2012. "Stochastic Amplification of Fluctuations in Cortical Up-States," PLOS ONE, Public Library of Science, vol. 7(8), pages 1-8, August.
    19. Rodrigo G. Fernandez Lahore & Niccolò P. Pampaloni & Enrico Schiewer & M.-Marcel Heim & Linda Tillert & Johannes Vierock & Johannes Oppermann & Jakob Walther & Dietmar Schmitz & David Owald & Andrew J, 2022. "Calcium-permeable channelrhodopsins for the photocontrol of calcium signalling," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    20. Leo Kozachkov & Mikael Lundqvist & Jean-Jacques Slotine & Earl K Miller, 2020. "Achieving stable dynamics in neural circuits," PLOS Computational Biology, Public Library of Science, vol. 16(8), pages 1-15, August.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jmathe:v:11:y:2023:i:19:p:4063-:d:1247188. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.