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Green Environments for Sustainable Brains: Parameters Shaping Adaptive Neuroplasticity and Lifespan Neurosustainability—A Systematic Review and Future Directions

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  • Mohamed Hesham Khalil

    (Department of Architecture, University of Cambridge, Cambridge CB2 1PX, UK)

Abstract

As global urbanisation is rising and public health challenges intensify, this systematic review is conducted at a critical time to explore and explain the associations between the parameters of green environments and nuanced adaptive neuroplasticity in the human brain to advance the development of health-focused sustainable cities and buildings in line with the concept of neurosustainability. This review includes studies involving participants of all ages and genders, with no restrictions on health conditions, exposed to green environments regardless of built environment comparisons. A systematic search of Scopus, PubMed, and Web of Science identified relevant studies published up to November 2024. The risk of bias was assessed using the PEDro scale and ROBINS-I domains, and data were analysed narratively due to heterogeneity. Twenty-three studies were included, conducted across the USA, UK, Germany, Spain, Bulgaria, the Netherlands, Japan, and South Korea. Findings reveal that green environments are associated with positive, region-specific brain changes across the lifespan, surprisingly from before birth to late adulthood. While forests showed more significant effects than blue spaces or urban green spaces, residential greenness emerged as a consistently effective exposure, especially within a 300–500 m buffer around home addresses, provided that sky visibility is present. Notably, no studies have examined green architecture or biophilic interiors, although they are more proximal, are associated with greater exposure time, have antagonistic effects, and may potentially limit sky visibility, highlighting a key gap for future research. Limitations include heterogeneity in exposure definitions, methodologies, and targeted brain regions. Still, this review offers a novel synthesis, providing insight into how greening the built environment may sustain not only the planet but also the plasticity of the brain. This review is registered with INPLASY (INPLASY2024110103) and forms part of a doctoral research project funded by the Cambridge Trust in partnership with the Jameel Education Foundation.

Suggested Citation

  • Mohamed Hesham Khalil, 2025. "Green Environments for Sustainable Brains: Parameters Shaping Adaptive Neuroplasticity and Lifespan Neurosustainability—A Systematic Review and Future Directions," IJERPH, MDPI, vol. 22(5), pages 1-28, April.
    • Handle: RePEc:gam:jijerp:v:22:y:2025:i:5:p:690-:d:1643367
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    References listed on IDEAS

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    1. Liisa Andersen & Sus Sola Corazon & Ulrika Karlsson Stigsdotter, 2021. "Nature Exposure and Its Effects on Immune System Functioning: A Systematic Review," IJERPH, MDPI, vol. 18(4), pages 1-48, February.
    2. Yukako Tani & Takeo Fujiwara & Genichi Sugihara & Masamichi Hanazato & Norimichi Suzuki & Masaki Machida & Shiho Amagasa & Hiroshi Murayama & Shigeru Inoue & Yugo Shobugawa, 2022. "Neighborhood Beauty and the Brain in Older Japanese Adults," IJERPH, MDPI, vol. 20(1), pages 1-10, December.
    3. Kühn, Simone & Düzel, Sandra & Mascherek, Anna & Eibich, Peter & Krekel, Christian & Kolbe, Jens & Goebel, Jan & Gallinat, Jürgen & Wagner, Gert G. & Lindenberger, Ulman, 2021. "Urban green is more than the absence of city: Structural and functional neural basis of urbanicity and green space in the neighbourhood of older adults," EconStor Open Access Articles and Book Chapters, ZBW - Leibniz Information Centre for Economics, vol. 214.
    4. Na’Taki Osborne Jelks & Viniece Jennings & Alessandro Rigolon, 2021. "Green Gentrification and Health: A Scoping Review," IJERPH, MDPI, vol. 18(3), pages 1-23, January.
    5. Fernando Fonseca & Marina Paschoalino & Lígia Silva, 2023. "Health and Well-Being Benefits of Outdoor and Indoor Vertical Greening Systems: A Review," Sustainability, MDPI, vol. 15(5), pages 1-18, February.
    6. Mohamed Hesham Khalil & Koen Steemers, 2024. "Housing Environmental Enrichment, Lifestyles, and Public Health Indicators of Neurogenesis in Humans: A Pilot Study," IJERPH, MDPI, vol. 21(12), pages 1-27, November.
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