IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v20y2023i4p3702-d1073704.html
   My bibliography  Save this article

Identification and Genetic Characterization of MERS-Related Coronavirus Isolated from Nathusius’ Pipistrelle ( Pipistrellus nathusii ) near Zvenigorod (Moscow Region, Russia)

Author

Listed:
  • Anna S. Speranskaya

    (Scientific Research Institute for Systems Biology and Medicine, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 117246 Moscow, Russia
    Central Research Institute for Epidemiology, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 111123 Moscow, Russia
    Biological Department, Lomonosov Moscow State University, 119234 Moscow, Russia)

  • Ilia V. Artiushin

    (Biological Department, Lomonosov Moscow State University, 119234 Moscow, Russia)

  • Andrei E. Samoilov

    (Scientific Research Institute for Systems Biology and Medicine, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 117246 Moscow, Russia
    Saint-Petersburg Pasteur Institute, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 197101 Saint-Petersburg, Russia)

  • Elena V. Korneenko

    (Scientific Research Institute for Systems Biology and Medicine, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 117246 Moscow, Russia)

  • Kirill V. Khabudaev

    (Scientific Research Institute for Systems Biology and Medicine, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 117246 Moscow, Russia)

  • Elena N. Ilina

    (Scientific Research Institute for Systems Biology and Medicine, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 117246 Moscow, Russia)

  • Alexander P. Yusefovich

    (Biological Department, Lomonosov Moscow State University, 119234 Moscow, Russia)

  • Marina V. Safonova

    (Department of Particularly Dangerous Diseases, Anti-Plague Center, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 127490 Moscow, Russia)

  • Anna S. Dolgova

    (Saint-Petersburg Pasteur Institute, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 197101 Saint-Petersburg, Russia)

  • Anna S. Gladkikh

    (Saint-Petersburg Pasteur Institute, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 197101 Saint-Petersburg, Russia)

  • Vladimir G. Dedkov

    (Saint-Petersburg Pasteur Institute, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 197101 Saint-Petersburg, Russia
    Martsinovsky Institute of Medical Parasitology, Tropical and Vector Borne Diseases, Sechenov First Moscow State Medical University, 119435 Moscow, Russia)

  • Peter Daszak

    (EcoHealth Alliance, New York, NY 10018, USA)

Abstract

Being diverse and widely distributed globally, bats are a known reservoir of a series of emerging zoonotic viruses. We studied fecal viromes of twenty-six bats captured in 2015 in the Moscow Region and found 13 of 26 (50%) samples to be coronavirus positive. Of P. nathusii (the Nathusius’ pipistrelle), 3 of 6 samples were carriers of a novel MERS-related betacoronavirus. We sequenced and assembled the complete genome of this betacoronavirus and named it MOW-BatCoV strain 15-22. Whole genome phylogenetic analysis suggests that MOW-BatCoV/15-22 falls into a distinct subclade closely related to human and camel MERS-CoV. Unexpectedly, the phylogenetic analysis of the novel MOW-BatCoV/15-22 spike gene showed the closest similarity to CoVs from Erinaceus europaeus (European hedgehog). We suppose MOW-BatCoV could have arisen as a result of recombination between ancestral viruses of bats and hedgehogs. Molecular docking analysis of MOW-BatCoV/15-22 spike glycoprotein binding to DPP4 receptors of different mammals predicted the highest binding ability with DPP4 of the Myotis brandtii bat (docking score −320.15) and the E. europaeus (docking score –294.51). Hedgehogs are widely kept as pets and are commonly found in areas of human habitation. As this novel bat-CoV is likely capable of infecting hedgehogs, we suggest hedgehogs can act as intermediate hosts between bats and humans for other bat-CoVs.

Suggested Citation

  • Anna S. Speranskaya & Ilia V. Artiushin & Andrei E. Samoilov & Elena V. Korneenko & Kirill V. Khabudaev & Elena N. Ilina & Alexander P. Yusefovich & Marina V. Safonova & Anna S. Dolgova & Anna S. Glad, 2023. "Identification and Genetic Characterization of MERS-Related Coronavirus Isolated from Nathusius’ Pipistrelle ( Pipistrellus nathusii ) near Zvenigorod (Moscow Region, Russia)," IJERPH, MDPI, vol. 20(4), pages 1-16, February.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:4:p:3702-:d:1073704
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/20/4/3702/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/20/4/3702/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Sarah Temmam & Khamsing Vongphayloth & Eduard Baquero & Sandie Munier & Massimiliano Bonomi & Béatrice Regnault & Bounsavane Douangboubpha & Yasaman Karami & Delphine Chrétien & Daosavanh Sanamxay & V, 2022. "Bat coronaviruses related to SARS-CoV-2 and infectious for human cells," Nature, Nature, vol. 604(7905), pages 330-336, April.
    2. Qing Xiong & Lei Cao & Chengbao Ma & M. Alejandra Tortorici & Chen Liu & Junyu Si & Peng Liu & Mengxue Gu & Alexandra C. Walls & Chunli Wang & Lulu Shi & Fei Tong & Meiling Huang & Jing Li & Chufeng Z, 2022. "Close relatives of MERS-CoV in bats use ACE2 as their functional receptors," Nature, Nature, vol. 612(7941), pages 748-757, December.
    3. Deborah Delaune & Vibol Hul & Erik A. Karlsson & Alexandre Hassanin & Tey Putita Ou & Artem Baidaliuk & Fabiana Gámbaro & Matthieu Prot & Vuong Tan Tu & Sokha Chea & Lucy Keatts & Jonna Mazet & Christ, 2021. "A novel SARS-CoV-2 related coronavirus in bats from Cambodia," Nature Communications, Nature, vol. 12(1), pages 1-7, December.
    4. Sarah Temmam & Khamsing Vongphayloth & Eduard Baquero & Sandie Munier & Massimiliano Bonomi & Béatrice Regnault & Bounsavane Douangboubpha & Yasaman Karami & Delphine Chrétien & Daosavanh Sanamxay & V, 2022. "Author Correction: Bat coronaviruses related to SARS-CoV-2 and infectious for human cells," Nature, Nature, vol. 607(7920), pages 19-19, July.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Luo-Yuan Xia & Zhen-Fei Wang & Xiao-Ming Cui & Yuan-Guo Li & Run-Ze Ye & Dai-Yun Zhu & Fang-Xu Li & Jie Zhang & Wen-Hao Wang & Ming-Zhu Zhang & Wan-Ying Gao & Lian-Feng Li & Teng-Cheng Que & Tie-Cheng, 2024. "Isolation and characterization of a pangolin-borne HKU4-related coronavirus that potentially infects human-DPP4-transgenic mice," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    2. Jing Wang & Yuan-fei Pan & Li-fen Yang & Wei-hong Yang & Kexin Lv & Chu-ming Luo & Juan Wang & Guo-peng Kuang & Wei-chen Wu & Qin-yu Gou & Gen-yang Xin & Bo Li & Huan-le Luo & Shoudeng Chen & Yue-long, 2023. "Individual bat virome analysis reveals co-infection and spillover among bats and virus zoonotic potential," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    3. Cedric C. S. Tan & Jahcub Trew & Thomas P. Peacock & Kai Yi Mok & Charlie Hart & Kelvin Lau & Dongchun Ni & C. David L. Orme & Emma Ransome & William D. Pearse & Christopher M. Coleman & Dalan Bailey , 2023. "Genomic screening of 16 UK native bat species through conservationist networks uncovers coronaviruses with zoonotic potential," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    4. Peter J. Halfmann & Kathryn Loeffler & Augustine Duffy & Makoto Kuroda & Jie E. Yang & Elizabeth R. Wright & Yoshihiro Kawaoka & Ravi S. Kane, 2024. "Broad protection against clade 1 sarbecoviruses after a single immunization with cocktail spike-protein-nanoparticle vaccine," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    5. Yelin Han & Panpan Xu & Yuyang Wang & Wenliang Zhao & Junpeng Zhang & Shuyi Zhang & Jianwei Wang & Qi Jin & Zhiqiang Wu, 2023. "Panoramic analysis of coronaviruses carried by representative bat species in Southern China to better understand the coronavirus sphere," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    6. David Hueting & Karen Schriever & Rui Sun & Stelios Vlachiotis & Fanglei Zuo & Likun Du & Helena Persson & Camilla Hofström & Mats Ohlin & Karin Walldén & Marcus Buggert & Lennart Hammarström & Harold, 2023. "Design, structure and plasma binding of ancestral β-CoV scaffold antigens," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    7. Juan Liu & Fengfeng Mao & Jianhe Chen & Shuaiyao Lu & Yonghe Qi & Yinyan Sun & Linqiang Fang & Man Lung Yeung & Chunmei Liu & Guimei Yu & Guangyu Li & Ximing Liu & Yuansheng Yao & Panpan Huang & Dongx, 2023. "An IgM-like inhalable ACE2 fusion protein broadly neutralizes SARS-CoV-2 variants," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    8. Cecilia A. Sánchez & Hongying Li & Kendra L. Phelps & Carlos Zambrana-Torrelio & Lin-Fa Wang & Peng Zhou & Zheng-Li Shi & Kevin J. Olival & Peter Daszak, 2022. "A strategy to assess spillover risk of bat SARS-related coronaviruses in Southeast Asia," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    9. Renata L. Muylaert & David A. Wilkinson & Tigga Kingston & Paolo D’Odorico & Maria Cristina Rulli & Nikolas Galli & Reju Sam John & Phillip Alviola & David T. S. Hayman, 2023. "Using drivers and transmission pathways to identify SARS-like coronavirus spillover risk hotspots," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:20:y:2023:i:4:p:3702-:d:1073704. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.