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Serotonin Receptor HTR3A Gene Polymorphisms rs1985242 and rs1062613, E-Cigarette Use and Personality

Author

Listed:
  • Aleksandra Suchanecka

    (Independent Laboratory of Health Promotion, Pomeranian Medical University in Szczecin, 11 Chlapowskiego St., 70-204 Szczecin, Poland)

  • Jolanta Chmielowiec

    (Department of Hygiene and Epidemiology, Collegium Medicum, University of Zielona Góra, Zyty 28 St., 65-046 Zielona Gora, Poland)

  • Krzysztof Chmielowiec

    (Department of Hygiene and Epidemiology, Collegium Medicum, University of Zielona Góra, Zyty 28 St., 65-046 Zielona Gora, Poland)

  • Grzegorz Trybek

    (Department of Oral Surgery, Pomeranian Medical University in Szczecin, 72 Powstanców Wlkp. St., 70-111 Szczecin, Poland)

  • Aleksandra Jaroń

    (Department of Oral Surgery, Pomeranian Medical University in Szczecin, 72 Powstanców Wlkp. St., 70-111 Szczecin, Poland)

  • Wojciech Czarny

    (Faculty of Physical Education, University of Rzeszów, Towarnickiego 3 St., 35-959 Rzeszów, Poland)

  • Paweł Król

    (College of Medical Sciences, Institute of Physical Culture Studies, University of Rzeszow, St. Towarnickiego 3, 35-955 Rzeszów, Poland)

  • Jolanta Masiak

    (Neurophysiological Independent Unit, Department of Psychiatry, Medical University of Lublin, 20-093 Lublin, Poland)

  • Anna Grzywacz

    (Independent Laboratory of Health Promotion, Pomeranian Medical University in Szczecin, 11 Chlapowskiego St., 70-204 Szczecin, Poland)

Abstract

We nowadays record growing numbers of e-cigarette users. The development of nicotine dependence is a result of many factors, including genetics and personality. In this study we analyzed two polymorphisms—rs1985242 and rs1062613—in the serotonin receptor HTR3A gene in a group of e-cigarette users ( n = 135) and controls ( n = 106). Personality traits were measured using the NEO Five-Factor Inventory. The comparison of e-cigarette users with the control group indicates that the former showed significantly higher scores on the neuroticism scale and lower scores on the scales of extraversion and conscientiousness of the NEO-FFI. Homozygote variants of rs1985242 were more frequent in the study group. The results of the 2 × 3 factorial ANOVA for e-cigarette users and the control group as well as interaction between the HTR3A rs1985242 variants were found for the NEO-FFI conscientiousness scale. These results allow us to conclude that the combination of psychological factors and genetic data creates a possibility for making more complete models of substance use disorders.

Suggested Citation

  • Aleksandra Suchanecka & Jolanta Chmielowiec & Krzysztof Chmielowiec & Grzegorz Trybek & Aleksandra Jaroń & Wojciech Czarny & Paweł Król & Jolanta Masiak & Anna Grzywacz, 2022. "Serotonin Receptor HTR3A Gene Polymorphisms rs1985242 and rs1062613, E-Cigarette Use and Personality," IJERPH, MDPI, vol. 19(8), pages 1-14, April.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:8:p:4746-:d:793725
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    References listed on IDEAS

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    1. Wipfli, H. & Avila-Tang, E. & Navas-Acien, A. & Kim, S. & Onicescu, G. & Yuan, J. & Breysse, P. & Samet, J.M., 2008. "Secondhand smoke exposure among women and children: Evidence from 31 countries," American Journal of Public Health, American Public Health Association, vol. 98(4), pages 672-679.
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    3. Anna Grzywacz & Jolanta Chmielowiec & Krzysztof Chmielowiec & Bożena Mroczek & Jolanta Masiak & Aleksandra Suchanecka & Olimpia Sipak-Szmigiel & Kamila Szumilas & Grzegorz Trybek, 2019. "The Ankyrin Repeat and Kinase Domain Containing 1 Gene Polymorphism ( ANKK1 Taq1A ) and Personality Traits in Addicted Subjects," IJERPH, MDPI, vol. 16(15), pages 1-13, July.
    4. Paul A. Davies & Marco Pistis & Michael C. Hanna & John A. Peters & Jeremy J. Lambert & Tim G. Hales & Ewen F. Kirkness, 1999. "The 5-HT3B subunit is a major determinant of serotonin-receptor function," Nature, Nature, vol. 397(6717), pages 359-363, January.
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    Cited by:

    1. Krzysztof Chmielowiec & Jolanta Chmielowiec & Aleksandra Strońska-Pluta & Grzegorz Trybek & Małgorzata Śmiarowska & Aleksandra Suchanecka & Grzegorz Woźniak & Aleksandra Jaroń & Anna Grzywacz, 2022. "Association of Polymorphism CHRNA5 and CHRNA3 Gene in People Addicted to Nicotine," IJERPH, MDPI, vol. 19(17), pages 1-12, August.

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