IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i3p1826-d742929.html
   My bibliography  Save this article

Effects of Polycyclic Aromatic Hydrocarbons on Lung Function in Children with Asthma: A Mediation Analysis

Author

Listed:
  • Giovanna Cilluffo

    (National Research Council of Italy, Institute for Biomedical Research and Innovation (IRIB), Via Ugo La Malfa 153, 90146 Palermo, Italy
    Department of Earth and Marine Sciences, University of Palermo, 90123 Palermo, Italy
    These authors should be considered joint first author.)

  • Giuliana Ferrante

    (Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, Pediatric Division, University of Verona, 37134 Verona, Italy
    These authors should be considered joint first author.)

  • Nicola Murgia

    (Section of Occupational Medicine, Respiratory Diseases and Toxicology, University of Perugia, 06123 Perugia, Italy)

  • Rosanna Mancini

    (National Center on Addiction and Doping, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy)

  • Simona Pichini

    (National Center on Addiction and Doping, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy)

  • Giuseppe Cuffari

    (Regional Agency for Environmental Protection of Sicily, 90146 Palermo, Italy)

  • Vittoria Giudice

    (Regional Agency for Environmental Protection of Sicily, 90146 Palermo, Italy)

  • Nicolò Tirone

    (Regional Agency for Environmental Protection of Sicily, 90146 Palermo, Italy)

  • Velia Malizia

    (National Research Council of Italy, Institute for Biomedical Research and Innovation (IRIB), Via Ugo La Malfa 153, 90146 Palermo, Italy
    National Research Council of Italy, Institute of Translational Pharmacology (IFT), Via Ugo La Malfa 153, 90146 Palermo, Italy)

  • Laura Montalbano

    (National Research Council of Italy, Institute for Biomedical Research and Innovation (IRIB), Via Ugo La Malfa 153, 90146 Palermo, Italy
    National Research Council of Italy, Institute of Translational Pharmacology (IFT), Via Ugo La Malfa 153, 90146 Palermo, Italy)

  • Salvatore Fasola

    (National Research Council of Italy, Institute for Biomedical Research and Innovation (IRIB), Via Ugo La Malfa 153, 90146 Palermo, Italy
    National Research Council of Italy, Institute of Translational Pharmacology (IFT), Via Ugo La Malfa 153, 90146 Palermo, Italy)

  • Roberta Pacifici

    (National Center on Addiction and Doping, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy)

  • Giovanni Viegi

    (National Research Council of Italy, Institute for Biomedical Research and Innovation (IRIB), Via Ugo La Malfa 153, 90146 Palermo, Italy
    National Research Council of Italy, Institute of Clinical Physiology (IFC), Via Trieste 41, 56126 Palermo, Italy
    These authors should be considered joint senior author.)

  • Stefania La Grutta

    (National Research Council of Italy, Institute for Biomedical Research and Innovation (IRIB), Via Ugo La Malfa 153, 90146 Palermo, Italy
    National Research Council of Italy, Institute of Translational Pharmacology (IFT), Via Ugo La Malfa 153, 90146 Palermo, Italy
    These authors should be considered joint senior author.)

Abstract

Studies investigating the association between urinary Polycyclic Aromatic Hydrocarbons (PAHs) and asthma in children provided inhomogeneous results. We aimed to use Mediation Analysis to discover whether a link between urinary PAHs and lung function exists and if it might be ascribed to a direct or a symptom-mediated (indirect) effect in children with asthma. This single-center prospective study was conducted in Palermo, Italy, between March and July 2017 and involved 50 children with persistent mild-moderate asthma, aged 6–11 years. At each time visit (day 0, 30, 60, and 90), physical examination, spirometry, and urine collection for detection of urinary cotinine and PAHs were performed. A symptom score was computed. The sum of individually calculated molar mass of nine PAH metabolites (ΣPAH), naphthalene metabolites (ΣPAHn) and phenanthrene metabolites (ΣPAHp) were calculated. Three children withdrew from the study due to technical problems ( n = 1) and adverse events ( n = 2). PAHs indirect effects on FEV 1 (ΣPAH: −0.011, p = 0.04; ΣPAH n : −0.011, p = 0.04; ΣPAH p : −0.012, p < 0.001) and FVC (ΣPAH: −0.012, p = 0.02; ΣPAH n : −0.0126, p = 0.02; ΣPAH p : −0.013, p < 0.001) were statistically significant. In conclusion, PAHs exposures have significant indirect (symptom-mediated) effects on lung function, emphasizing the role of PAHs-induced respiratory morbidity in decreasing lung function in children with asthma.

Suggested Citation

  • Giovanna Cilluffo & Giuliana Ferrante & Nicola Murgia & Rosanna Mancini & Simona Pichini & Giuseppe Cuffari & Vittoria Giudice & Nicolò Tirone & Velia Malizia & Laura Montalbano & Salvatore Fasola & R, 2022. "Effects of Polycyclic Aromatic Hydrocarbons on Lung Function in Children with Asthma: A Mediation Analysis," IJERPH, MDPI, vol. 19(3), pages 1-14, February.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:3:p:1826-:d:742929
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/3/1826/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/19/3/1826/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Angelica I. Tiotiu & Plamena Novakova & Denislava Nedeva & Herberto Jose Chong-Neto & Silviya Novakova & Paschalis Steiropoulos & Krzysztof Kowal, 2020. "Impact of Air Pollution on Asthma Outcomes," IJERPH, MDPI, vol. 17(17), pages 1-29, August.
    2. Sotiris Vardoulakis & Evanthia Giagloglou & Susanne Steinle & Alice Davis & Anne Sleeuwenhoek & Karen S. Galea & Ken Dixon & Joanne O. Crawford, 2020. "Indoor Exposure to Selected Air Pollutants in the Home Environment: A Systematic Review," IJERPH, MDPI, vol. 17(23), pages 1-24, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Melania Maria Serafini & Ambra Maddalon & Martina Iulini & Valentina Galbiati, 2022. "Air Pollution: Possible Interaction between the Immune and Nervous System?," IJERPH, MDPI, vol. 19(23), pages 1-24, November.
    2. Pierre Lemire & Sofia Temam & Sarah Lyon-Caen & Catherine Quinot & Etienne Sévin & Sophie Remacle & Karine Supernant & Rémy Slama & Orianne Dumas & Valérie Siroux & Nicole Le Moual & the SEPAGES Study, 2021. "Comparison of a Barcode-Based Smartphone Application to a Questionnaire to Assess the Use of Cleaning Products at Home and Their Association with Asthma Symptoms," IJERPH, MDPI, vol. 18(7), pages 1-13, March.
    3. Annette M. Krais & Julie Y. Essig & Louise Gren & Carolina Vogs & Eva Assarsson & Katrin Dierschke & Jörn Nielsen & Bo Strandberg & Joakim Pagels & Karin Broberg & Christian H. Lindh & Anders Gudmunds, 2021. "Biomarkers after Controlled Inhalation Exposure to Exhaust from Hydrogenated Vegetable Oil (HVO)," IJERPH, MDPI, vol. 18(12), pages 1-15, June.
    4. Mengting Liao & Yi Xiao & Shenxin Li & Juan Su & Ji Li & Bin Zou & Xiang Chen & Minxue Shen, 2022. "Synergistic Effects between Ambient Air Pollution and Second-Hand Smoke on Inflammatory Skin Diseases in Chinese Adolescents," IJERPH, MDPI, vol. 19(16), pages 1-12, August.
    5. Le Zhang & Qinyi Gu & Chen Li & Yi Huang, 2022. "Characteristics and Spatial–Temporal Differences of Urban “Production, Living and Ecological” Environmental Quality in China," IJERPH, MDPI, vol. 19(22), pages 1-22, November.
    6. Szymon Hoffman & Mariusz Filak & Rafał Jasiński, 2022. "Air Quality Modeling with the Use of Regression Neural Networks," IJERPH, MDPI, vol. 19(24), pages 1-33, December.
    7. Yun-Gi Lee & Pureun-Haneul Lee & Seon-Muk Choi & Min-Hyeok An & An-Soo Jang, 2021. "Effects of Air Pollutants on Airway Diseases," IJERPH, MDPI, vol. 18(18), pages 1-17, September.
    8. Tun Z. Maung & Jack E. Bishop & Eleanor Holt & Alice M. Turner & Christian Pfrang, 2022. "Indoor Air Pollution and the Health of Vulnerable Groups: A Systematic Review Focused on Particulate Matter (PM), Volatile Organic Compounds (VOCs) and Their Effects on Children and People with Pre-Ex," IJERPH, MDPI, vol. 19(14), pages 1-24, July.
    9. Yuping Dong & Helin Liu & Tianming Zheng, 2021. "Association between Green Space Structure and the Prevalence of Asthma: A Case Study of Toronto," IJERPH, MDPI, vol. 18(11), pages 1-25, May.
    10. Shereen Elshaer & Lisa J. Martin & Theresa A. Baker & Erin Roberts & Paola Rios-Santiago & Ross Kaufhold & Melinda Butsch Kovacic, 2023. "Environmental Health Knowledge Does Not Necessarily Translate to Action in Youth," IJERPH, MDPI, vol. 20(5), pages 1-14, February.
    11. Natalia Sauer & Wojciech Szlasa & Laura Jonderko & Krystyna Głowacka & Katarzyna Karłowicz-Bodalska & Anna Wiela-Hojeńska, 2022. "Contrast Media Adverse Drug Reactions in Highly Polluted Environment," IJERPH, MDPI, vol. 19(12), pages 1-13, June.
    12. Angelica Tiotiu & Iulia Ioan & Nathalie Wirth & Rodrigo Romero-Fernandez & Francisco-Javier González-Barcala, 2021. "The Impact of Tobacco Smoking on Adult Asthma Outcomes," IJERPH, MDPI, vol. 18(3), pages 1-12, January.
    13. Gabriela Martins Costa Gomes & Wilfried Karmaus & Vanessa E. Murphy & Peter G. Gibson & Elizabeth Percival & Philip M. Hansbro & Malcolm R. Starkey & Joerg Mattes & Adam M. Collison, 2021. "Environmental Air Pollutants Inhaled during Pregnancy Are Associated with Altered Cord Blood Immune Cell Profiles," IJERPH, MDPI, vol. 18(14), pages 1-16, July.
    14. Maria Chiara Pietrogrande & Lucia Casari & Giorgia Demaria & Mara Russo, 2021. "Indoor Air Quality in Domestic Environments during Periods Close to Italian COVID-19 Lockdown," IJERPH, MDPI, vol. 18(8), pages 1-12, April.
    15. Hélène Niculita-Hirzel, 2022. "Latest Trends in Pollutant Accumulations at Threatening Levels in Energy-Efficient Residential Buildings with and without Mechanical Ventilation: A Review," IJERPH, MDPI, vol. 19(6), pages 1-12, March.
    16. Hanna Maria Elonheimo & Tiina Mattila & Helle Raun Andersen & Beatrice Bocca & Flavia Ruggieri & Elsi Haverinen & Hanna Tolonen, 2022. "Environmental Substances Associated with Chronic Obstructive Pulmonary Disease—A Scoping Review," IJERPH, MDPI, vol. 19(7), pages 1-13, March.
    17. Kelton Mock & Anton M. Palma & Jun Wu & John Billimek & Kim D. Lu, 2022. "Breathing Room: Industrial Zoning and Asthma Incidence Using School District Health Records in the City of Santa Ana, California," IJERPH, MDPI, vol. 19(8), pages 1-12, April.
    18. Amy Dymond & Stuart Mealing & Jessica McMaster & Hayden Holmes & Lesley Owen, 2021. "Indoor Air Quality at Home—An Economic Analysis," IJERPH, MDPI, vol. 18(4), pages 1-13, February.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:3:p:1826-:d:742929. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.